Half a minute made all the difference as the Tennessee Titans' defence made two huge plays in quick succession to stun the Los Angeles Rams 28-16 in the NFL on Sunday.

Rams quarterback Matthew Stafford threw two interceptions in a 26-second span early in the second quarter, leading to a pair of rapid-fire Titans touchdowns. 

The first was an ill-advised attempt to throw the ball away while being dragged down in the end zone that David Long intercepted at the Rams' eight-yard line.

After Geoff Swaim scored on a two-yard TD pass from Titans QB Ryan Tannehill on the ensuing play, Stafford's next pass was picked off and returned 24 yards for a TD by Kevin Byard. 

Tannehill would run the ball in for another score prior to half-time as the Titans built a 21-3 lead before handing the game over to their ferocious defence, which sacked Stafford five times after LA entered the game with only eight sacks allowed all season. 

Titans recruit Adrian Peterson scored his 125th career TD, joining 11 other players to score 125-plus career touchdowns.

The Rams (7-2) would not find the end zone until Stafford hit Sony Michel for a short TD with 24 seconds remaining in the game as they fell behind the victorious Arizona Cardinals (8-1) in the division race. 

Tennessee (7-2) now hold the best record in the AFC despite being out-gained 347-194 as star running back Derrick Henry remains sidelined with a foot injury.

Tannehill completed 19 of 27 passes for just 143 yards with a TD and an interception but his 79.7 passer rating was still better than Stafford's 71.0 after the Rams QB finished 31-of-48 passing for 294 yards.