Defending champions Kansas City have a 9-1 record this season, while the Buccaneers are 7-3.
Though Tampa have lost two of their past three games, the Chiefs' most recent two victories have been by tight margins, and now an all-time great in the form of six-time Super Bowl champion Brady goes up against the league's current star quarterback.
The game in Florida is among the key Thanksgiving weekend matchups we preview with Stats Perform data.
FEATURED GAME
Kansas City Chiefs at Tampa Bay Buccaneers - Sunday, 4:25pm (all times Eastern)
- This game is a matchup of the quarterbacks who won the past two Super Bowls, with Brady winning Super Bowl LIII two seasons ago with the New England Patriots and Mahomes and the Chiefs winning the Lombardi Trophy last February. The Bucs are 1-4 this season versus QBs who have started in Super Bowls, and 6-0 in all other games.
- Kansas City have reeled off five straight victories, scoring 30 or more points in each of the last four contests. In the franchise's 61-year history, the team has scored 30 or more points in five successive games on two occasions, in 2004 and 2018 (both streaks ended at five games).
- With a 13.5 touchdown-interception ratio (27 TD passes, two picks), Mahomes is tied for the second best single-season mark among qualifiers in league history. He is topped by only Brady and his 14.0 mark in 2016 as a member of the Patriots (28 and two).
- Twenty years and six days after making his NFL debut, Brady will look to snap a two-game home losing streak. It is the third time in his career and first since 2006 that the veteran campaigner has lost consecutive home contests in the regular season; he has never suffered a three-game home losing streak.
OTHER KEY GAMES
Arizona Cardinals at New England Patriots - Sunday, 1pm
- New England have won six of the last seven games between these teams dating back to 1993, with Arizona's only win coming in 2012 in Foxborough. The Cardinals have not scored more than 21 points in any of those seven games – they had at least 24 in six of the first seven all-time meetings between these teams (6-1).
Tennessee Titans at Indianapolis Colts - Sunday, 1pm
- Ryan Tannehill has 44 touchdown passes and nine interceptions in his 20 starts with Tennessee. His 4.89 TD/INT ratio is the best all-time by a quarterback in his first 20 starts with a team, surpassing Peyton Manning with the Denver Broncos (4.82).
Chicago Bears at Green Bay Packers - Sunday, 8:20pm
- Green Bay are 15-3 against Chicago since the 2011 season – the third best record by one team against a divisional opponent in that span, behind the Patriots against the New York Jets (17-2) and the Steelers against the Cinciannati Bengals (16-3). Since the start of last season, the Bears have gone 14 games scoring fewer than 20 points. Only the Jets (17), Bengals (15), and Washington (15) have had more such games.
Seattle Seahawks at Philadelphia Eagles - Monday, 8:15pm
- The Eagles are 2-5 against the Seahawks in Philadelphia, their worst home record against any active franchise. Losers of the last five such matchups, Philly have not dropped six consecutive home games to a single opponent since losing six straight to the Cardinals from 1973 to 1978.
ELSEWHERE...
Los Angeles Chargers at Buffalo Bills - Sunday, 1pm
- The Chargers have won four straight over the Bills by a combined 80 points, winning each by double digits. The last time the Bills beat the Chargers was on October 19, 2008 – that 12-year span without a win is the fourth-longest active drought by any team against a conference opponent.
Las Vegas Raiders at Atlanta Falcons - Sunday, 1pm
- Atlanta's Matt Ryan is set to play in his 200th career game on Sunday. His tally of 54,164 passing yards (though 199 games) is the second-most in NFL history in a player's first 200 games, trailing only Drew Brees (55,439).