Tom Brady threw a costly pick-six to ice a 36-27 win for the New Orleans Saints over NFL Super Bowl champions the Tampa Bay Buccaneers.

All eyes were on Saints quarterback Jameis Winston in his reunion with the Buccaneers, having moved to New Orleans in April last year following five mixed seasons with Tampa Bay.

But Winston was carted off the field in the second quarter against his former team, suffering a knee injury during a horse-collar tackle by Buccaneers linebacker Devin White.

Winston had completed six of 10 passes for 56 yards and a touchdown while scrambling for 40 yards before exiting the game with the score tied 7-7.

Led by veteran backup Trevor Siemian, the Saints (5-2) still held on to sink Brady's Buccaneers (6-2) on home turf, despite the latter becoming the all-time leader for most three-plus passing TD games in NFL history (98).

Four touchdown passes from seven-time Super Bowl champion Brady helped the Buccaneers overturn a 23-7 deficit – Tampa Bay moving ahead 27-26 following a 50-yard throw to Cyril Grayson just over five minutes from the end.

But Brian Johnson's field goal with less than two minutes remaining restored New Orleans' lead, albeit by two points, before P.J. Williams picked off Brady – his second interception of the contest – for a 40-yard interception return to seal the win.

Broncos block two field goals

The Denver Broncos and their defence held firm to see off the lowly Washington Football Team 17-10.

Denver blocked two field goals en route to their fourth win of the season, snapping a four-game skid.

Dre'Mont Jones (in the fourth quarter) and Shelby Harris (in the second period) each blocked field-goal attempts from Chris Blewitt as the Broncos avoided going winless in October for the first time since 1967.