Russell Wilson produced a vintage performance to lead the Seattle Seahawks past the San Francisco 49ers 28-21.
Wilson celebrated his 100th NFL victory as the Seahawks (2-2) rallied past the 49ers (2-2) in San Francisco on Sunday.
The Super Bowl champion finished 16-of-23 passing for two touchdowns, while he rushed for another TD on four carries.
Wilson joined Hall of Famer Peyton Manning as the second quarterback in NFL history to win 100 games in their first 10 seasons.
The 49ers – with Jimmy Garoppolo starting under center – took an early 7-0 lead but that was as good as it got for San Francisco on home soil.
Wilson's 12-yard pass to DK Metcalf ensured the scores were tied at half-time before the former dominated in the third period – the eight-time Pro Bowler's 16-yard run putting the Seahawks 14-7 ahead and Freddie Swain then caught a throw to stretch the lead to 14 points.
Trey Lance – who completed nine of his 18 passes for 157 yards and two TDs – replaced Garoppolo (calf) in the second half and the rookie QB kept the 49ers in the contest with a monster 76-yard TD pass to Deebo Samuel during the closing stages of the third quarter.
After an Alex Collins touchdown gave the Seahawks a 28-13 lead early in the final period, Lance combined with Samuel again at the death, but it was too little, too late.
Cardinals stay unbeaten behind Murray
Kyler Murray inspired the high-flying Arizona Cardinals to a 37-20 win at the previously undefeated Los Angeles Rams.
Murray passed for 268 yards and two touchdowns, while running for 39 more yards as the red-hot Cardinals improved to 4-0 this season.
Meanwhile, Aaron Rodgers and Randall Cobb guided the Green Bay Packers to a third consecutive win – a 27-17 victory over the Pittsburgh Steelers.
Rodgers and Cobb connected for two touchdowns and ran for another score at home to the Steelers.
Packers superstar Rodgers threw his 420th career TD pass – tying Dan Marino for sixth all-time.
Under-fire Steelers QB Ben Roethlisberger threw his 400th career touchdown pass – the eighth player to do so.