Ryan Tannehill looks set to miss the rest of the season as the Tennessee Titans quarterback likely requires surgery on a right-ankle injury.

The one-time Pro Bowler saw his game curtailed during Sunday's loss to the Los Angeles Chargers, after outside linebacker Khalil Mack landed on his foot.

Tannehill was carted from the field before returning with his ankle heavily strapped, though he was unable to prevent the Titans slipping to a 17-14 defeat.

Reports from ESPN now indicate the 34-year-old's campaign looks to be over, with the former Miami Dolphins man set to undergo an operation for the problem.

It was a right ankle injury that ruled Tannehill out of two games following a week six match with the Indianapolis Colts, bringing Malik Willis into the fold in his place.

The reserve quarterback started in practice on Tuesday and Wednesday, while the Titans have also signed Joshua Dobbs to provide additional backup.

The latter was with the Detroit Lions briefly as part of their practice squad earlier this month, after he was waived following Deshaun Watson's return to the fold at the Cleveland Browns.

Tennessee are 7-7 for the year, and sit atop the AFC South, but have not won in their last four outings to leave their postseason hopes precariously balanced heading into the final few weeks.

They play the Houston Texans on Saturday, before closing games against the Dallas Cowboys and the Jacksonville Jaguars, with the latter their main rival to top the division.