The Los Angeles Rams placed star wide receiver Puka Nacua on injured reserve Monday after he re-aggravated a right knee injury in Sunday night’s season opener.

Nacua will miss a minimum of four games. With the Rams’ bye Week falling in Week 6, the earliest Nacua could be back on the field is Oct. 20.

Nacua missed most of training camp due to a PCL sprain in his right knee. He re-injured the knee in the second quarter of Los Angeles’ Week 1 overtime loss against the Detroit Lions.

“It’s unfortunate for him, and I’m bummed out for the person,” Rams coach Sean McVay told reporters on Monday.

With Nacua missing the entire second half Sunday, Cooper Kupp was targeted 21 times and made 14 catches for 110 yards and a touchdown. Tyler Johnson finished second on the team in receiving with five receptions for 79 yards.

Johnson will be among the receivers asked to step up in Nacua’s absence, along with DeMarcus Robinson and rookie Jordan Whittington.

Nacua will miss division games against the Arizona Cardinals and San Francisco 49ers, as well as dates against the Chicago Bears and Green Bay Packers.

A fifth-round pick out of BYU last year, Nacua had arguably the best rookie receiving season in NFL history. Nacua set rookie records with 105 receptions for 1,486 yards in 2023.