The New England Patriots' Week 5 game against the Denver Broncos has been postponed after their training facility was shut down in the wake of a new positive coronavirus test.

Patriots cornerback Stephon Gilmore tested positive for COVID-19, it emerged on Wednesday, becoming the team's second high-profile case after Cam Newton.

Quarterback Newton missed the Week 4 trip to the Kansas City Chiefs, with that game pushed back a day as a result of isolated cases for both teams.

The NFL's official website reported that a further positive test occurred on Saturday, causing the training base to be closed. It did not name the Patriots player involved. 

In a short statement, the NFL confirmed the Patriots and the Broncos would now have a bye week in light of a COVID-19 positive, with a new date for the game to be announced in due course.

"The Denver Broncos at New England Patriots game scheduled for Monday, October 12 at 5:00 pm ET has been postponed," the statement read.

"Details on a new game date and time will be announced shortly. Both teams will now have a Week 5 bye.

"This decision was made to ensure the health and safety of players, coaches and game day personnel and in consultation with medical experts."

New England lost 26-10 to the Chiefs, slipping to 2-2 for the season.

The Broncos encounter was initially moved to Monday from Sunday due to the closure of the Patriots' practice facility, which only re-opened on Saturday.