The NFL is back and, for so many across the globe, that means it's time to examine the matchup data and prepare fantasy rosters for Week 1.

Unless you've left it remarkably late, fantasy drafts are in the rear-view mirror and it's time to set the best line-up to deliver an opening-week win.

But which players are ideally positioned to help fantasy managers start the year with a victory?

Here, Stats Perform looks at four players and a defense poised to deliver big fantasy points.

Quarterback – Kyler Murray, Arizona Cardinals @ Tennessee Titans

The pressure is firmly on Cardinals head coach Kliff Kingsbury and Murray to deliver in year three of their partnership after they collapsed from 6-3 to miss the playoffs.

But if the Cardinals make a disappointing start to 2021, it is more likely to be because of their defense than Murray, who can do great damage against a Tennessee defense vulnerable to the ground game and to what the Arizona quarterback can do with his legs.

Tennessee gave up the fourth-most fantasy points per game to opposing quarterbacks last season. The Titans' 6.84 yards per pass play allowed was the 11th-worst rate in the NFL, while they were tied for the 10th-most rushing touchdowns conceded with 18.

Murray, who had 31 passing plays of 25 yards or more, ninth-most in the league, and averaged the second-most yards per carry (6.15) last season, is ideally equipped to take advantage of those vulnerabilities and put together a substantially productive fantasy day.

Running Back – James Robinson, Jacksonville Jaguars @ Houston Texans

Robinson's stock looked to have been dealt a major blow when the Jaguars drafted Travis Etienne in the first round having selected his former Clemson team-mate Trevor Lawrence first overall.

But a season-ending foot injury to Etienne ruled him out for the year, meaning Robinson will get the bulk of the carries in the Jacksonville backfield.

He is coming off a tremendous rookie year that saw him rack up 1,070 rushing yards while averaging 2.34 yards after contact per attempt, the sixth-best rate in the NFL.

And he has the perfect matchup to carry that momentum into the new season, facing a Texans team in disarray amid the Deshaun Watson saga that gave up a league-worst 5.2 yards per rush last season.

If you have Robinson, start him.

Wide Receiver – Brandon Aiyuk, San Francisco 49ers @ Detroit Lions

Week 1 often delivers some weirdness but, on paper, the Niners could not have asked for a better matchup than the rebuilding Lions.

The Lions gave up 7.85 yards per pass play, the most in the NFL last season, and their young secondary is one San Francisco head coach Kyle Shanahan should have little trouble exploiting.

Jeff Okudah, the Lions' first-round pick from 2020 and starting cornerback, gave up a burn – when a receiver wins his matchup with a defender on a play where he is targeted – on 68.2 per cent of his targets. He conceded 15.28 burn yards per target, the third-most in the NFL.

As the 49ers' top wideout, Aiyuk will be frequently matched up with Okudah and, after producing a big play on 33.1 per cent of his targets – the third-most among rookie wideouts with at least 50 targets – in his first season, this extremely gifted route-runner has a clear opportunity to make a hot start to a potential breakout year.

Tight End – Dallas Goedert, Philadelphia Eagles @ Atlanta Falcons

It's difficult to get too excited about the Eagles offense, given it averaged 224 net passing yards per game since Jalen Hurts took over as the starting quarterback in Week 14 last year, 21st in the NFL.

But the two players who averaged the most targets per game for the Eagles in that time were their tight ends, Zach Ertz and Goedert. Ertz averaged 5.8 targets and Goedert 5.7 while playing a game fewer.

Goedert is the younger and more explosive of that pair and should command a higher share of the targets going forward. Facing a Falcons team that gave up 7.18 yards per pass play last year and conceded the third-most fantasy points per game to tight ends, Goedert's role in the offense is a recipe for him opening the season in stunning fashion.

Defense – Los Angeles Rams vs. Chicago Bears

Justin Fields will not be starting for the Bears against the Rams, and the first-round rookie might consider himself fortunate given the discrepancy between the talent on the Rams' defensive front and the Bears' offensive line.

The Chicago O-Line is 30th in Stats Perform's rankings, which is a poor position to be in at any point of the season but is especially troubling ahead of a matchup with a Los Angeles team that tallied 50 sacks for negative yardage in 2020.

Chicago allowed 23.8 per cent of points on giveaways last season and, with their O-Line facing reigning Defensive Player of the Year Aaron Donald, who beat a pass protector on 94 of his 103 pressures last term, the Bears appear poised to concede more points in that manner and reward fantasy players who invested in the Rams' defense.