Cam Newton made history and the New England Patriots humiliated the Los Angeles Chargers 45-0 in the NFL, while the Kansas City Chiefs booked their place in the playoffs.

Newton inspired Sunday's demolition of the hapless Chargers in Inglewood, California, where the Patriots kept their postseason hopes alive.

Reigning champions the Chiefs overcame the Denver Broncos to punch their ticket to the playoffs yet again as the New York Giants claimed a huge upset against the Seattle Seahawks.

NEWTON STANDS ALONE IN NFL AS PATS RUN RIOT

Patriots quarterback Newton was at the forefront of New England's ruthless demolition of the Chargers on the road.

Newton ran for two touchdowns to become the only NFL quarterback with double-digit rushing TDs in three different seasons, while he also set the league record for most multiple-touchdown games in a season by a QB with four in 2020.

The former MVP finished 12-of-19 passing for 69 yards and a touchdown, while he carried for 48 yards and a pair of TDs as the Patriots claimed back-to-back wins to improve to 6-6.

It was the 29th shutout in New England's history and 12th under head coach Bill Belichick, who moved past Tom Landry for third-most games coached with 455.

According to Stats Perform, New England's win was the largest road shut-out victory in NFL history by a team that entered the game with a losing record.

Los Angeles (3-9) were condemned to their worst loss in franchise history, eclipsing a 49-6 demolition against Kansas City in 1964.

CHIEFS FIRST AFC TEAM INTO PLAYOFFS

The Chiefs were far from their best but still trumped the Broncos 22-16 to secure a spot in the postseason for the sixth successive campaign – a franchise record.

Kansas City improved to 11-1 for the season after seeing off Denver for the 11th consecutive time, a streak dating back to 2015.

The Chiefs, who are yet to clinch a fifth straight AFC West title, saw star quarterback Patrick Mahomes finish 25 of 40 for 318 yards, a touchdown and no interceptions.

Mahomes has thrown for at least 300 yards in five consecutive games, having achieved the feat last season and the campaign prior. Via Stats Perform, he is the only quarterback to have a five-plus game streak in three successive seasons.

Travis Kelce caught a touchdown as he posted his fifth consecutive season with 1,000-plus receiving yards – no other tight end in league history even has five total seasons of 1,000 receiving yards, per NFL Research.

Kelce is also the first TE in the Super Bowl era with 1,100-plus receiving yards in his team's first 12 games of a season. He set the previous record in 2018.

Denver's Drew Lock completed 15 of 28 passes for 151 yards, two touchdowns and as many interceptions on the road.

GIANTS CLIP SEAHAWKS' WINGS, RODGERS MAKES HISTORY

In what has been described as one of Seattle's worst losses of the Pete Carroll era, the Giants stunned the Seahawks 17-12.

The Giants were 4-7 entering the clash, while the NFC West-leading Seahawks were looking to extend their advantage.

But the Giants – using backup quarterback Colt McCoy – had other ideas against Russell Wilson and the Seahawks, who were outscored 14-0 in the third quarter.

Wilson struggled on home turf in Seattle, where he was sacked five times and finished 27-of-43 passing for 263 yards, one touchdown and one interception.

The Seahawks and Los Angeles Rams are now level atop the NFC West with 8-4 records after the latter beat the Arizona Cardinals 38-28.

Meanwhile, Aaron Rodgers became the fastest player to throw 400 career touchdown passes in the Green Bay Packers' 30-16 success against the Philadelphia Eagles.

Rodgers reached the milestone in his 193rd NFL appearance, eclipsing Drew Brees, Tom Brady, Peyton Manning, Dan Marino, Brett Favre and Philip Rivers after finding team-mate Davante Adams in the third quarter.

After throwing three touchdown passes, Super Bowl champion Rodgers also became the first player in league history with 35-plus TD passes in five different seasons.

Week 13 scores:

Cleveland Browns 41-35 Tennessee Titans
Las Vegas Raiders 31-28 New York Jets
Minnesota Vikings 27-24 Jacksonville Jaguars
Miami Dolphins 19-7 Cincinnati Bengals
Indianapolis Colts 26-20 Houston Texans
Detroit Lions 34-30 Chicago Bears
New Orleans Saints 21-16 Atlanta Falcons
Los Angeles Rams 38-28 Arizona Cardinals
New York Giants 17-12 Seattle Seahawks
New England Patriots 45-0 Los Angeles Chargers
Green Bay Packers 30-16 Philadelphia Eagles
Kansas City Chiefs 22-16 Denver Broncos