Kyler Murray and DeAndre Hopkins are both game-time decisions for the Arizona Cardinals, head coach Kliff Kingsbury has confirmed.
Arizona travel to play NFC West rivals the San Francisco 49ers on Sunday, looking to bounce back from suffering their first loss of the year against the Green Bay Packers.
Murray threw multiple picks and no touchdowns in a game for the first time in his career as Arizona lost 24-21 to the Packers, ending the only perfect record left in the NFL.
The Cardinals (7-1) could be without their starting quarterback and leading wide receiver on the road against the Niners.
Murray (ankle) and Hopkins (hamstring) both missed the open section of practice on Friday, having also not been involved on Wednesday or Thursday.
"He is progressing but we will see how he feels Sunday and go from there," Kingsbury said about Murray.
"I know he wants to play. He knows how important a divisional game is [but] we are not going to put him out there if he can't function.
"I don't know if [Hopkins] will go full speed or not."
Arizona (7-1) got a 17-10 win at home over San Francisco (3-4) this season, but that was the only game in which they have not scored at least 21 points this year.
Murray has had a spectacular year so far, putting himself in the MVP conversation.
The third-year QB ranks second for completion percentage (72.7) and has 17 touchdown passes to seven interceptions, as well as a further three scores on the ground.
Murray's 24 passing plays of 25-plus yards are tied for the most in the NFL with Tom Brady, and he leads an efficient offense which has led him to the fourth-highest passer rating (110.4) in 2021.
Veteran backup Colt McCoy will play if Murray is unable to take the field.
Hopkins leads the team in catches (35) and receiving yards (486), but at 60.8 yards per game is operating well below his production from last season (87.9) amid his injury struggles.
The Cardinals also put wide receiver A.J. Green on the reserve/COVID-19 list this week.
The 49ers, meanwhile, beat the Bears 33-22 in Chicago last week, snapping a four-game losing streak and scoring their most points since a 41-33 win over the Detroit Lions in Week 1.
In an unusual sequence of results since the start of last season, the Niners are 1-10 at home and 8-4 on the road.