Patrick Mahomes turned in a stellar display as he led Super Bowl champions the Kansas City Chiefs to a huge win over the New York Jets.
The Chiefs ran out 35-9 winners on Sunday, with quarterback Mahomes at his inspired best.
Elsewhere, the Buffalo Bills picked up a 24-21 victory against the New England Patriots – their first home win against the six-time league champions since 2011.
MAHOMES INSPIRES RAMPANT CHIEFS
There was no stopping the Chiefs in their home clash with the Jets, whose dismal start to the season never looked likely to end.
The Jets are 0-8 after a wonderful display from Kansas City, who were marshalled brilliantly by Mahomes as the star threw for 416 yards and five touchdowns.
AFC West leaders Kansas stemmed Sam Darnold from the off, and the visiting quarterback could only watch as Mahomes ran the show.
Darnold did not have his top receivers Jamison Crowder and Breshad Perriman to aim for due to injuries and was only 18 of 30 for 133 yards as the Jets fell to 0-8 for the first time since 1996.
Kansas' triumph also took head coach Andy Reid onto 229 wins – tying him with Hall of Famer Curly Lambeau for the fifth-most in NFL history.
Second in the AFC West are the Las Vegas Raiders, who overcame the Cleveland Browns – third in the AFC North – 16-6.
BILLS SNAP PATRIOTS STREAK, GRANT STUNS RAMS
The Bills ended a nine-year wait for a home victory over the Patriots as they claimed a 24-21 win in Buffalo.
Cam Newton's fumble on a late drive ultimately cost the Patriots, who are now 2-5 from their opening seven games.
As well as marking Sean McDermott's first triumph over Patriots coach Bill Belichick, it is a win that moved the Bills (6-2) to 4-0 in the AFC East.
New England had not lost an away game at Buffalo since September 2011, while the Bills had not beaten the Patriots at all in seven games prior to the Week 8 clash.
Meanwhile, Jakeem Grant scored a stunning touchdown to help the Miami Dolphins to a 28-17 success over the Los Angeles Rams.
Grant ran in a mesmerising 88-yard punt return – the first this season in the NFL – helping the Dolphins, who sit second in the AFC East, to a fourth victory of the season.
In an all-NFC North clash, the Minnesota Vikings clinched a 28-22 win over their rivals Green Bay Packers at Lambeau Field.
Dalvin Cook was the star with four touchdowns – three running and one receiving.
STEELERS STAY PERFECT
The Pittsburgh Steelers are the only unbeaten team remaining after they maintained their winning start with a dramatic 28-24 triumph over the Baltimore Ravens.
Lamar Jackson looked set to win it for the hosts in the dying seconds in Baltimore, yet AFC North leaders Pittsburgh clung on thanks to some fantastic defense.
With the last throw of the game, Jackson attempted to pick out Willie Snead in the end zone, but his flat pass was knocked down by a combination of Justin Layne and Minkah Fitzpatrick.
Defeat leaves the Ravens at 5-2 and second in the division, which is stacked up by the Cincinnati Bengals (2-5-1), who shocked the Tennessee Titans.
Joe Burrow was key, with the quarterback completing 26 of his 37 passes for 249 yards and two touchdowns.
Burrow also avoided any sacks, as the Bengals sealed a 31-20 victory – their second home win of 2020.
In Sunday's other game, the Indianapolis Colts halted the Detroit Lions' two-game winning streak with a 41-21 rout.
Week 8 scores:
Atlanta Falcons 25-17 Carolina Panthers
Buffalo Bills 24-21 New England Patriots
Cincinnati Bengals 31-20 Tennessee Titans
Las Vegas Raiders 16-6 Cleveland Browns
Indianapolis Colts 41-21 Detroit Lions
Minnesota Vikings 28-22 Green Bay Packers
Kansas City Chiefs 35-9 New York Jets
Miami Dolphins 28-17 Los Angeles Rams
Pittsburgh Steelers 28-24 Baltimore Ravens