The Indianapolis Colts have ruled running-back Jonathan Taylor out of contention for Thursday's clash against the Denver Broncos due to an ankle injury.

Taylor suffered a twisted ankle in Sunday's defeat to the Tennessee Titans but was hopeful that he would be able to feature in the opening game of Week 5.

"I definitely do plan to play, but if you can't go you can't go. That's why you have to get as much treatment as you can," he said on Tuesday.

However, the Colts announced on Wednesday that Taylor was among four players officially listed as out for the meeting in Denver, alongside safety Julian Blackmon (ankle), linebacker Shaquille Leonard (concussion/nose/back) and defensive end Tyquan Lewis.

Nyheim Hines is likely set to see increased usage on the ground in Taylor's absence, having largely been an aerial presence for the Colts this season – just 11 of his 124 yards in 2022 coming from rushing plays.

The Colts stand 1-2-1 for the season ahead of facing the Broncos, who they boast a 7-3 record against from their last 10 meetings.