The San Francisco 49ers survived a fourth-quarter comeback from the Dallas Cowboys to claim a dramatic 23-17 upset win in the Wild Card round.

Despite losing Nick Bosa to a concussion and linebacker Fred Warner to an ankle injury, the 49ers' defense held a Cowboys offense that led the NFL in yards per game with 407 to just 17 points, and it was the resistance of that group that ultimately proved decisive.

Yet such a summation does a disservice to a wild finish in which the Niners looked to have won the game several times, only to give the Cowboys hope as this historic rivalry delivered another classic in the first playoff meeting between the two teams since the 1994 season.

Dallas got the ball back with 32 seconds left and needing a touchdown to win and moved to San Francisco's 41-yard line in three plays, but an inexplicable decision to run the ball with quarterback Dak Prescott saw time expire on the game and the Cowboys' season as the 49ers progressed to a Divisional Round meeting with the Green Bay Packers at Lambeau Field.

The 49ers set their stall out with a dominant seven-play, 75-yard drive to start the game that ended with a four-yard touchdown scamper by rookie running back Elijah Mitchell.

San Francisco tacked on two field goals to make it 13-0 before Prescott hit back with a superb 20-yard touchdown pass to Amari Cooper.

Another three-pointer gave San Francisco a 16-7 half-time lead and their defense continued to hold Prescott in check after the break even with star edge rusher Bosa ruled out. 

Prescott was sacked five times and when he was intercepted by K'Waun Williams and versatile wide receiver Deebo Samuel pounced on that turnover with a 26-yard rushing touchdown a blowout appeared on the cards.

Dallas, though, pulled back within 13 points with a Greg Zuerlein field goal and an overthrown interception by Jimmy Garoppolo teed up Prescott to fray the nerves with a five-yard rushing score.

San Francisco's job looked to be done when a deep fourth-down throw from Prescott fell incomplete and the Niners should have been celebrating victory when Garoppolo executed a quarterback sneak on fourth and inches, only for that play to be called back for a false start.

However, the Cowboys could not capitalise on that reprieve despite their initial progress down the field, Prescott and center Tyler Biadasz forgetting that an official needed to spot the ball after his run in the final seconds, with a collision between a referee and Biadasz before he spotted the ball meaning the clock hit triple zeros before the quarterback could spike it to set up a Hail Mary attempt.