Thomas Tuchel's side took a deserved lead into half-time thanks to a fine finish from Kai Havertz, who had scored the winner in the Champions League final in May.
Havertz clipped a clever shot high beyond Bernd Leno after being played into space by Timo Werner, who missed a good chance for a second three minutes later.
The Gunners, who brought on new signing Ben White at half-time, drew level 69 minutes in when Granit Xhaka headed in Nicolas Pepe's cross.
However, Chelsea's lead was restored within four minutes as Tammy Abraham slotted a precise finish beneath Leno following a mistake by Hector Bellerin.
Arsenal should have been given an equaliser when Joe Willock crashed a shot off the crossbar and the ball appeared to bounce over the line, but with goal-line technology not in use, it was not awarded.
Mikel Arteta will also be concerned to see midfielder Thomas Partey forced to go off with what appeared to be an ankle injury in the first half.
Chelsea will now face Tottenham on Wednesday before Arsenal take on their north London neighbours on August 8.
The inaugural Maradona Cup will take place at Mrsool Park in Riyadh on December 14, a little over a year after the former Argentina star died in his homeland at the age of 60 from heart failure a fortnight after undergoing brain surgery.
Maradona played for Boca in 1981-82 before moving to Europe with Barca, where he won the Copa del Rey, the Copa de la Liga and the Supercopa de Espana.
He returned to Boca for the final two years of his career before retiring in 1997.
The match will take place in the week after Barca face Bayern Munich away in their final Champions League group game, with a LaLiga game at Osasuna scheduled for December 11.
Ronald Koeman's side will be due back in Saudi Arabia in January 2022 for the Supercopa de Espana along with Real Madrid, Atletico Madrid and Athletic Bilbao.
Barca and Boca have met 10 times previously, most recently in the Joan Gamper exhibition game in 2018, which the Catalans won 3-0.
The joy of winning last year's delayed Euro 2020 tournament has been replaced by rapid deflation after Italy failed to qualify for the World Cup.
Having also missed out on the Russia 2018 finals, falling short of a place at Qatar 2022 represented crushing disappointment for the four-time winners.
Chiellini, the 37-year-old defensive titan who is leaving Juventus and expected to join Los Angeles FC, has called time on his Italy career.
He played the first half on Wednesday in a 3-0 defeat to Argentina at Wembley, in a match tagged as the Finalissima, a clash of the champions of Europe and South America.
"We were hoping to win the match and the trophy," Chiellini told Italian broadcaster RAI. "We knew it would be tough, but the defeat does not cancel what has gone before.
"Now I expect a difficult period. We need everyone to support this group."
Chiellini lasted just 45 minutes in his farewell game, with Italy 2-0 up by the time he departed.
This was the first staging of the CONMEBOL/UEFA 'Cup of Champions' since 1993. Lautaro Martinez, Angel Di Maria and Paulo Dybala got the goals as Lionel Messi pulled the strings
It was a sorry way for Chiellini to go out, and he said: "It's a shame because in the first half we made a lot of mistakes and we ruined the match by ourselves."
Turning his attention to Argentina, he added: "Above all, at this moment they are too strong, they have confidence and they are a team. They look like us a year ago."
Italy, without Chiellini, will switch their focus to the Nations League. They face Germany on Saturday and again on June 14 – matches against Hungary and England are sandwiched in between.
Writing on his Instagram page, Chiellini reflected on the end of a 117-cap career.
He wrote: "Thanks to everyone, it's been a beautiful journey."
Spain and Italy have been two of the hardest-hit European nations during the COVID-19 outbreak, recording 27,709 and 32,007 deaths, respectively.
Everyday life – including sport – has seen massive changes across both countries over the past two months, with lockdown measures only recently beginning to be eased.
The three European giants will play matches next year to determine the winner of the European Solidary Cup, but the main purpose will be to aid the purchasing of healthcare supplies and express gratitude to medical professionals for their work during the pandemic.
The matches will be played across each of the three cities, with the tournament announced for 2021 in the hope fans will once again be able to attend.
A statement released by Los Blancos read: "Real Madrid are set to team up with Bayern Munich and Inter to host the European Solidarity Cup in 2021. The three clubs will come together to send out a message of solidarity and fraternity to the people of Europe.
"The solidarity event will see three football matches held during 2021 in the cities of Madrid, Munich and Milan. The dates for these games will depend on the competitive calendar and of course will take place when the fans are able to return to the stands.
"The three teams will all come up against each other: Madrid vs Inter will happen in Madrid, Inter vs Bayern is set for Milan and Bayern vs Madrid will be held in Munich. The proceeds from these games will go towards the purchase of healthcare resources in Italy and Spain.
"Healthcare staff who continue to fight the pandemic will be represented at all of the games. The three clubs wish to demonstrate to these heroes all of our solidarity, respect and gratitude."
Bayern resumed their 2019-20 Bundesliga campaign on Sunday with a 2-0 win over Union Berlin.
LaLiga and Serie A are not expected to recommence until next month at the earliest, however.
Harry Maguire and Jadon Sancho were on target in the first half of Thursday's encounter, with Dominic Calvert-Lewin's emphatic penalty completing a routine outing after the break.
Manager Gareth Southgate will now have plenty to think about after a strong showing from a number of England's fringe players prior to matches with Belgium and Iceland.
The visitors' hopes of earning a first ever Wembley win were dealt a blow when John Egan was forced off early on after taking a bang to the head.
Ireland probed with a couple of dangerous low crosses but England hit the front from a corner that resulted from Darren Randolph saving smartly from Bukayo Saka following an initial poor punch.
Harry Winks picked up the first clearance and stood up a cross for Maguire to power home with his head.
Calvert-Lewin then went close at the end of a slick move and Randolph saved from Maguire before the lively Jack Grealish fed Sancho, who lashed home England's second through the legs of Jeff Hendrick.
England picked up where they left off in the second half, pressing Ireland high before Saka was tripped in the box by Cyrus Christie.
And Calvert-Lewin made no mistake from the spot, hammering the ball into the top corner for the second goal of his short international career.
With the hosts in complete control late on, Southgate introduced Jude Bellingham from the bench, making him the third youngest England player of all-time.
What does it mean? Southgate given headache
The wisdom of playing these international friendlies has been questioned in recent weeks, but there is no doubt that Southgate learned more about the depth at his disposal this evening.
There is nothing better for a manager than to see fringe players stepping up in the absence of key men and that is exactly what happened for England here. Southgate is facing a very welcome headache.
Grealish makes case once again
It once felt like there was nothing Grealish could do to get into the England squad, but just two caps in he already looks a dead cert for inclusion in the Euros squad next summer.
The Aston Villa man was influential again here, taking 50 touches, completing 88.9% of passes in the opposition half, and making two key passes - including the assist for Sancho's goal.
Idah isolated up top
Starting up front for the visitors at Wembley, Adam Idah would have hoped to make much more of an impact before his withdrawal in the 71st minute.
The 19-year-old touched the ball just 18 times, and won only one of his five duels.
What's next?
England travel to Belgium for a Nations League fixture on Sunday, while Ireland's next outing in the same competition sees them face Wales away from home.
Newcastle will face German clubs Mainz and 1860 Munich in Austria ahead of the 2022-23 season.
But the scheduled matches have not been welcomed by supporters of those clubs due to the identity of Newcastle's owners.
The consortium that bought Newcastle last October includes Saudi Arabia's Public Investment Fund (PIF), which owns 80 per cent of the club.
Saudi Arabia's human rights record is of major concern, along with its role in the war in Yemen.
But Mainz insist they cannot afford to cancel the Newcastle friendly, both because of the need to prepare for the Bundesliga season and due to contractual obligations.
"A friendly against a big English club is first of all a really good test for us," said chairman Stefan Hofmann in a statement in which Mainz confirmed they had held further talks with Newcastle and would plan to meet with fans. "It's also important for our team’s pre-season preparations.
"After weighing up our options and not having an appropriate alternative opponent of this standard available, we agreed to play this game.
"We didn't expect the reaction we got from some fans. We respect them and regret that these concerns have arisen because it's our responsibility to start the new season as one big unit together with our fans."
Mainz board member Christian Heidel added: "From a footballing perspective, we can't afford to miss out on this friendly.
"A one-sided cancellation of the fixture, as has been demanded by some fans, is not feasible, because were we to not honour our contractual obligations, this could have serious legal and economic consequences for us, and so we're going to stand by the contractual agreement."
Mainz coach Bo Svensson had already addressed the concerns, saying as reported by Bild: "On the one hand, I can understand the arguments.
"[But] whenever it comes to football, things get very inflated and become huge issues."
Referring to the PIF's shares in Disney, Svensson added: "How far are we going? Will we then also forego Disney films with our children?"
1860 coach Michael Kollner said to db24: "You always have to be a bit careful when conducting a moral discussion. I find that difficult. You can find something in everyone.
"We haven't done everything right in the past either – and teams are still playing against us in preparation.
"Newcastle was bought by someone with the money he has. I don't know if we are always entitled to evaluate things – especially in times when we have completely different issues in Europe.
"Unity looks different. I'm responsible for the sport – and I'm glad we got this test match."
Argentina were comprehensive 3-0 winners at Wembley, as the CONMEBOL/UEFA 'Cup of Champions' was revived for the first time since 1993.
Lautaro Martinez, Angel Di Maria and Paulo Dybala got the goals as Lionel Messi pulled the strings, but in truth Italy were fortunate to only lose 3-0 against a hugely impressive Albiceleste.
It was only Italy's second match since their shock World Cup qualifying defeat to North Macedonia in March, with that loss preventing them from reaching Qatar 2022.
Despite the Azzurri winning Euro 2020 less than a year ago, Mancini is already looking to instigate something of a rebuild.
But he was keen to pay tribute to those who have played a key role over the past four years.
"In the first half we made two mistakes on their two goals, then they were better at keeping the ball," Mancini is quoted as saying by Sky Italia.
"They were better than us, but I must say thanks to these guys who have played in these four years.
"There is regret for the lack of qualification for the World Cup, and tonight's match was initially balanced, then they had superior quality to us.
"After this match we had in mind to change several things and we will do it. We need to find the players, put together a team that will suffer at the beginning and that in the future will be able to give us joy."
Clearly, the attack will be Mancini's primary focus in any rebuild as he rued a lack of threat going forward.
"We have great difficulty scoring at the moment, and we have to work a lot knowing that it will not be so simple and it will take time [to overcome their issues]," he continued.
"After the European Championship we struggled to score and we have to find solutions in this sense and try to be fast, but it will not be easy to put together a team that gives us short-term satisfaction even if there are good guys. We will have to make as few mistakes as possible.
"I have optimism. I like to work and train. It's true that we lost against a great Argentina team, but we must know that there will also be these moments and we must make sure that the youngest players learn quickly."
Italy now turn their attention to the Nations League. They face Germany on Saturday and again on June 14 – matches against Hungary and England are sandwiched in between.
Martinez's Belgium were without several key players including star Kevin De Bruyne, Axel Witsel, Eden Hazard and Thibaut Courtois for the pre-Euro 2020 warm-up fixture in Brussels.
Thorgan Hazard – brother of Real Madrid's Eden – opened the scoring off his shin in the 20th minute from a Yannick Carrasco assist.
Greece equalised in the 66th minute after Kyriakos Papadopoulos' header hit the post, with Georgios Tzavellas reacting first for the visitors.
Despite failing to win, Martinez was content with the result as they fine-tune ahead of the rescheduled European Championship, where top-ranked Belgium are one of the favourites.
Martinez offered rare praise of an individual, singling out 19-year-old Rennes forward Doku following his seventh international appearance.
The former Anderlecht man only scored two goals and provided three assists in Ligue 1 in 2020-21 but is highly rated in his native Belgium, bursting on to the international scene with a goal in his second Red Devils appearance last September.
"I'm very, very satisfied with some of the individual performances," Martinez said after the game. "It seems Jeremy Doku had exactly the same impact he had in March.
"He's looking always to be getting stronger and better. Not only when he has the ball but in general in many actions of the game he's involved in. He worked well tonight."
The Spaniard added: "Yannick Carrasco was very strong in both halves of the field. Romelu Lukaku also showed that he was having a very good time mentally.
"Then there is Dennis Praet, for a player who has not played for so long, it's really nice to see that he managed the 90 minutes well. It's very good to see such a good response from all the players."
Greece failed to qualify for the Euros, but Martinez was not too fazed by his side's inability to beat the 2004 champions.
"We needed a game like this," he said. "You don't learn anything that you win 3 or 4-0.
"I wanted a competitive team like the ones we are going to face at the Euros. That's why we chose Greece. We knew it would not be a friendly match against them.
"I am not disappointed because this game was not scheduled to be won. It was played so that all the players could level up.
"Many players have accumulated the playing time necessary for the Euros."
Belgium, whose Euro 2020 campaign starts against Russia on June 12, will play Croatia in their final warm-up fixture on Sunday.
La Roja travel to Lisbon this week to face Portugal on Wednesday in the first meeting between the sides since the 2018 World Cup group stages.
Ronaldo scored a hat-trick, which included a stunning late free-kick, on that occasion to earn a 3-3 draw with Spain in Sochi.
Former Barcelona boss Luis Enrique has previously sided with Messi in the debate over who is the greatest modern player, describing the Blaugrana number 10 as the best in the world "in every position" and "the best in the history of football".
However, he has huge admiration for the way Juventus forward Ronaldo continues to strive for success at the age of 35 and after spending 18 years in senior football.
"Our goal doesn't change aside from the fact confronting a player of his profile can be motivational," he told reporters on Tuesday as he looked ahead to the friendly at Estadio Jose Alvalade.
"As a team, we will try to do things better than Portugal and try to cause them problems – that's the goal. Whether Ronaldo plays or not, the situation, the general approach to the game doesn't change.
"With regards to your other question, if you check through your newspaper archives, you already knew what my opinion is and I don't think it will be ideal for me again to comment on who is the best player in the world for me.
"What is worthy of praise is the fact that players like Cristiano and Leo Messi keep getting older but maintaining such a high level thanks to their professionalism, their ambition and their capacity to be motivated and keep achieving goals. Both Cristiano and Messi are examples of that."
Ronaldo has scored three goals and set up another in his first two Serie A appearances of 2020-21, with Juve beating Sampdoria 3-0 and then drawing 2-2 with Roma.
Messi has one goal in three LaLiga matches, with Barca beating Villarreal 4-0, Celta Vigo 3-0 and drawing 1-1 with Sevilla in Ronald Koeman's first three league games in charge.
The annual MLS All-Star Game sees a squad made up of players from across the league come together to face an opponent.
For the last two years, the MLS All-Stars have played a Liga MX All-Stars team, with the team from the United States' top tier emerging victorious on both occasions.
However, the 2023 edition will see the MLS All-Stars return to playing a European club, with Arsenal appearing in the exhibition event for a second time.
The Gunners beat an All-Stars side that included Andrea Pirlo, Kaka, Didier Drogba and David Villa 2-1 in San Jose in 2016.
This year's match will be held at Audi Field in Washington, D.C, with England's joint-record goalscorer Rooney – who coaches D.C. United in MLS – set to take charge of the All-Stars.
"I've had a front-row seat to watch the growth and development of Major League Soccer, first as a player and now as a manager," said Rooney in a statement.
"The opportunity to lead the best our league has to offer against a top Premier League club like Arsenal will be a highlight for me personally and an unforgettable experience for our passionate fanbase here in D.C."
Mikel Arteta said: "It's great that we're playing against the MLS All-Stars in Washington D.C. in July.
"Our US tour [in 2022] was very good preparation for the season, and we're looking forward to once again visiting our amazing supporters in the US. The match against the MLS All-Stars will be a good test ahead of the 2023-24 season."
On July 18, 10 Arsenal players will also go up against 10 MLS players in the Skills Challenge, which will again be held at Audi Field.
Arsenal are eight points clear at the top of the Premier League with 10 games remaining, while Rooney's D.C. United are 11th in the Eastern Conference in MLS with four points from as many games this season.
