Arizona converted a field goal with only seconds remaining in overtime as the Cardinals completed a thrilling 37-34 comeback win over the previously unbeaten Seahawks on Sunday.
Brady surpassed New Orleans Saints counterpart Drew Brees for a league record, while Super Bowl champions the Kansas City Chiefs and San Francisco 49ers also won.
CARDINALS SOAR AS SEAHAWKS FALL
In one of the games of the season, the Cardinals triumphed thanks to Zane Gonzalez's field goal with 15 seconds remaining in Arizona.
The Seahawks – led by MVP candidate Russell Wilson – appeared on track to improve to 6-0, having led 27-17 at half-time and 34-24 heading into the final three minutes of regulation.
But the Cardinals rallied – Kyler Murray's eight-yard pass to Christian Kirk reducing the deficit to three points before Gonzalez converted a 44-yard field goal to force OT.
Gonzalez had the chance to settle the contest with a field goal early in OT but missed, however, the Cardinals kicker redeemed himself at the death.
Murray finished 34-of-48 for 360 yards, three touchdowns and an interception, while Wilson was 33-of-50 for 388 yards, three TDs and as many interceptions.
In a remarkable showdown, Seattle wide receiver DK Metcalf produced a sensational chase-down, delivering a touchdown-saving tackle on Budda Baker's 90-yard interception return in the second quarter.
RECORD-SETTING BRADY INSPIRES BUCS
Bucs quarterback Brady moved top of the NFL's all-time list for touchdown passes after leading Tampa Bay to a 45-20 rout of the Raiders.
Brady replaced Brees for the most TD passes in league history with his throw to Tyler Johnson in the fourth quarter.
A six-time Super Bowl champion, Brady eclipsed Brees' record with his 559th career touchdown pass, one ahead of his Saints counterpart.
Brady completed 33 of 45 passes for 369 yards and four touchdowns, with no interceptions or sacks against the Raiders (3-3) as NFC South leaders the Buccaneers improved to 5-2 for the season.
Rob Gronkowski, Scotty Miller – who finished with 109 yards – Chris Godwin and Johnson all connected with Brady for TDs, while Raiders QB Derek Carr was 24-of-36 for 284 yards, two touchdowns, an interception and three sacks.
CHIEFS TAKE DOWN BRONCOS, 49ERS THRASH NEWTON'S PATS
Patrick Mahomes and the Chiefs were too good for the Broncos, winning 43-16 on the road.
Played in snow, the Chiefs (6-1) led 24-9 at half-time and never looked back as they claimed their 10th consecutive victory over AFC West rivals the Broncos (2-4).
Mahomes extended his NFL-leading streak to 17 successive games with a touchdown throw, finishing 15-of-23 for 200 yards and a touchdown, while Le'Veon Bell impressed on debut after rushing for 39 yards on six carries.
It was a forgettable outing for Cam Newton and the New England Patriots, who were easily beaten 33-6 by the 49ers in Foxborough.
Newton – who was nine-of-15 for 98 yards – threw three interceptions and was replaced in the fourth quarter as the Patriots slumped to their third consecutive loss.
Former Patriots QB Jimmy Garoppolo enjoyed his return to New England, where the 49ers star was 20-of-25 for 277 yards, no touchdowns and two interceptions.
"It was a cool week," Garoppolo said. "Just a lot of emotions, a lot of memories. Especially coming back here, seeing the same stadium, hearing the same songs they used to play, a lot of memories came back... But it was a fun night.
"Couldn't imagine it going any better than this."
Meanwhile, Justin Herbert threw three touchdowns as the Los Angeles Chargers defeated the Jacksonville Jaguars 39-29.
Week 7 scores:
Philadelphia Eagles 22-21 New York Giants
Pittsburgh Steelers 27-24 Tennessee Titans
Washington Football Team 25-3 Dallas Cowboys
Buffalo Bills 18-10 New York Jets
New Orleans Saints 27-24 Carolina Panthers
Green Bay Packers 35-20 Houston Texans
Cleveland Browns 37-34 Cincinnati Bengals
Detroit Lions 23-22 Atlanta Falcons
Tampa Bay Buccaneers 45-20 Las Vegas Raiders
San Francisco 49ers 33-6 New England Patriots
Kansas City Chiefs 43-16 Denver Broncos
Los Angeles Chargers 39-29 Jacksonville Jaguars
Arizona Cardinals 37-34 Seattle Seahawks (OT)