Daniil Medvedev took the first spot in the men's semi-finals at the US Open as he beat qualifier Botic van de Zandschulp in four sets on Tuesday.

Second seed Medvedev was two sets up with just over an hour played at Arthur Ashe Stadium, yet was ultimately made to work for a 6-3 6-0 4-6 7-5 triumph.

The Russian, a beaten finalist at Flushing Meadows in 2019 and a semi-finalist last year, broke Van de Zandschulp three times in the opening set, which he took at the fourth time of asking as his Dutch opponent offered up the first sign it would not be an easy day for the favourite.

Medvedev wrapped up a second set bagel with ease, though Van de Zandschulp – who beat in-form world number 11 Casper Ruud en route to the quarters – found some resolve in the third.

Unforced errors from the world number two handed Van de Zandschulp hope and the 25-year-old stuck 91 per cent of his first-serve points to take advantage.

Medvedev's wobble was short lived, however, with his composure regaining as he held his serve in what proved to be the final set.

A match point went begging as Medvedev missed the chance to break, but victory was assured on Van de Zandschulp's next serve, with a drop shot nestling into the net.

Next up for Medvedev is Felix Auger-Aliassime or Carlos Alcaraz, with the latter the youngest men's quarter-finalist at the US Open in the Open Era.

Data Slam: Medvedev's serve too strong

Medvedev won a whopping 83 per cent of his first serve points, converting 54 of 65, and finished with 13 aces. "I'm really happy with my serve in the fourth set, and to get through without a tie-break," he said. Indeed, in the final set, the 25-year-old's first serve percentage was up at 85. 

WINNERS/UNFORCED ERRORS

Van de Zandschulp – 36/35
Medvedev – 36/24

ACES/DOUBLE FAULTS

Van de Zandschulp – 4/4
Medvedev – 13/1

BREAK POINTS WON

Van de Zandschulp – 2/5
Medvedev – 7/12