Stan Wawrinka mounted an impressive comeback victory on his return to action at the Monte Carlo Masters, but Andy Murray went out in straight sets.
The pair, both three-time grand slam winners, enjoyed contrasting fortunes in their first-round matches against Tallon Griekspoor and Alex de Minaur.
Wawrinka, who has not played since Indian Wells last month, saw off the Dutchman in a 5-7 6-3 6-4 triumph, but Murray was routed by the Australian in a 6-1 6-3 loss.
"It was really important to stay calm with myself," Wawrinka said. "In the first round you need to find your game. I am happy to get through. It was important to fight until the end."
Roberto Bautista Agut saved a match point in the second-set tie-break as he fought back to overcome Filip Krajinovic to prevail 5-7 7-6 (12-10) 6-1.
Dominic Thiem is also through following a 6-1 6-4 win over Richard Gasquet but 11th seed Cameron Norrie is out after suffering a 6-3 6-4 loss to Francisco Cerundolo.