Seattle Seahawks Russell Wilson has set his sights on more wins and NFL championships after celebrating his 100th career victory.

Wilson reached a century of regular-season wins in the NFL following the Seahawks' 28-21 success against the San Francisco 49ers on Sunday.

Already a Super Bowl champion, Wilson finished 16-of-23 passing for two touchdowns, while he rushed for another TD on four carries.

Wilson joined Hall of Famer Peyton Manning as the second quarterback in NFL history to win 100 games in their first 10 seasons, though the eight-time Pro Bowler became the fastest to triple digits.

"I'm excited about the next hundred," Wilson said. "There's more championships. There's more things we want to do."

Wilson was the star of the show as the Seahawks (2-2) ended a run of back-to-back defeats.

The 32-year-old produced a vintage performance, with his touchdown pass to Freddie Swain one of the highlight reel.

Wilson spun away from a blitzing Dontae Johnson and avoided Nick Bosa before finding Swain for the TD.

"I thought Russ was spectacular today," Seahawks head coach Pete Carroll said post-game. "It was so hard early.

"He just stayed the course, stayed with it and really kind of recaptured a chance to win this game when you wouldn't think there was any way. It just didn't look like it was going to happen."

Wilson added: "Both of them right there — 'uh oh'. I've had some good plays in my career. That was definitely a good one."

"I was speechless, man," Seahawks offensive lineman Duane Brown said of the moment. "I just went to him and said, 'You're a bad [expletive]'.

"That's my words to him. That's one of the best plays I've seen from him in my time here. But with him, it's just commonplace."