The San Francisco 49ers had a dominant second half to end the Los Angeles Chargers' dominance over them with a 22-16 victory at Levi's Stadium on Sunday.

The Niners' running game came to the fore in the second half, taking the lead for the first time with 7:54 remaining in the fourth quarter after Christian McCaffrey's touchdown.

San Francisco went 12-0 in the second half, turning around a 16-10 half-time deficit, ending the Chargers' five-game streak against them. The win means San Francisco claimed back-to-back victories to improve to 5-4, while the Chargers dip to 5-4 having lost two of their past three games.

The Niners enjoyed more possession, rushing for 157 yards compared to the Chargers' 51, with Elijah Mitchell (89 yards on 18 carries) and Deebo Samuel (27 yards on four carries) contributing well on their returns from injury.

Niners quarterback Jimmy Garoppolo completed 15 of 23 passes for 197 yards with no touchdowns or interceptions, although he ran in a TD late in the first half.

Garoppolo linked up with Brandon Aiyuk, who had six receptions for 84 yards, on a 24-yard pass leading to McCaffrey's decisive rushing two-yard TD.

The Chargers scored on the opening drive of the game when QB Justin Herbert pinpointed DeAndre Carter on a 32-yard deep left pass.

In the final two minutes, a one-handed Josh Palmer could not reel in a desperate fourth-down pass from Herbert, who finished the game on 21-of-35 passing for 196 yards with one TD and one interception, before Robbie Gould made it a six-point game with a 20-yard field goal.