George Kittle will be absent for the San Francisco 49ers for the second week in a row, having been ruled out of Sunday's division match-up against the Seattle Seahawks.

The Pro Bowl tight end missed the 49ers' shock Week 1 loss to the Chicago Bears with a groin injury but returned to practice on Friday, though he carried a questionable status.

Kittle has now been officially ruled as inactive for Week 2, marking the fourth consecutive season where he has missed multiple games.

After last week's loss to the Bears, the 49ers are 6-9 in games without Kittle during his career, including losses in six of their last seven without him.

San Francisco have lost four in a row to the Seahawks, who begun their season with a surprising victory against the Denver Broncos in Russell Wilson's return to Seattle.