The Philadelphia Eagles may have already won the NFC East and will enter Week 16 without quarterback Jalen Hurts, but a clash with the Dallas Cowboys remains the standout game on the slate.
While the Cowboys' attempts to stick with the Eagles this year were hampered by their road form, Dallas are strong at home and will hope to send a warning to their division rivals ahead of a playoff campaign in which both teams will hope to feature prominently.
Elsewhere, the Kansas City Chiefs have work to do still as they aim, like the Eagles, to secure a bye with the number one seed in the AFC.
But it is not all about the NFL's leading lights, with the battle for position ahead of the postseason ongoing – with a big game in store in Charlotte.
Stats Perform picks out the key facts ahead of a busy Christmas weekend...
Philadelphia Eagles (13-1) @ Dallas Cowboys (10-4)
In beating the Chicago Bears last week, the Eagles secured a 13th win in a single season for only the third time in franchise history. On the two previous occasions, Philly finished with a 13-3 record and reached the Super Bowl, losing to the New England Patriots in the 2004 season and beating the same team in 2017.
The Eagles have never won 14 games in a regular season and will be without injured QB Hurts as they aim to end a four-game losing streak in Dallas.
But the Cowboys are coming into this big home game on a downer, having blown a 17-point lead against the Jacksonville Jaguars last week for their first loss in five.
That game also again showed big QB performances can sometimes prove immaterial, with Dak Prescott throwing for 256 yards and three touchdowns. The Cowboys are 1-2 this season when Prescott has thrown three or more TD passes and only 7-6 since 2020. Prior to that, they were 13-3 in such games.
Seattle Seahawks (7-7) @ Kansas City Chiefs (11-3)
Patrick Mahomes and Geno Smith each earned Pro Bowl selections this week – a fifth for Mahomes but only a first for Smith. Both were well deserved, with the pair third and second respectively for passer rating among qualifying players this year (Smith, 105.3, and Mahomes, 105.0).
However, Mahomes will look to do something he has never done before on Saturday: beat the Seahawks. Having lost 38-31 to Seattle in his only previous such clash in 2018, they are one of just two teams Mahomes has played but never beaten (also 0-2 against the Indianapolis Colts).
Smith, who has never faced the Chiefs, leads the NFC with 26 touchdown passes as he aims to follow Russell Wilson (2017 and 2018) and Matt Hasselbeck (2005) as the only Seahawks to lead the conference across a season. However, with eight interceptions and four fumbles lost by Smith, Seattle are the sole team in the league to have committed a turnover in every game this year.
Detroit Lions (7-7) @ Carolina Panthers (5-9)
The Lions' stunning 6-1 run, including an active three-game winning streak, has them firmly in playoff contention in the NFC. The last time they won six out of seven games in a single season, back in 2016, was also the last time they made the postseason.
However, the Lions have a miserable history against the Panthers. Their 3-7 record in this matchup is their worst against any current NFC franchise, while Detroit are 0-5 on the road against the Panthers since winning on their first trip in 1999.
With Jared Goff in the best form of his career, the Lions will hope to snap that streak. He has gone six games without an interception, which ties the longest such streak by a Lions QB since the statistic was first tracked in 1960. Goff had never previously gone more than three games without throwing a pick.
Elsewhere...
The Bears this week face the Buffalo Bills, the only team in the Super Bowl era to have lost more consecutive games with 125 or more rushing yards in each loss. Chicago have lost seven in a row, but the 1976 Bills were defeated in 10. With 2,616 rushing yards but a 3-11 record, the Bears are on course to become the first team to lead the league in rushing yards yet have one of the worst two records since the 1932 Staten Island Stapletons.
Recent history suggests the Minnesota Vikings will follow up last week's record-breaking comeback against the Colts with another win over the New York Giants. The Vikings' 7-2 record against the Giants since 2005 is their best against NFC opposition and New York's worst.
The Patriots will have to upset the Cincinnati Bengals to get their playoff bid back on track, yet they have won their past seven home games in this matchup, including the last four while scoring at least 35 points. The last team to win five in a row at home to any one team while scoring 35 points or more were the San Francisco 49ers against the Atlanta Falcons between 1992 and 1996.
Tua Tagovailoa will be relieved this week's game against the Green Bay Packers is in Miami and not Wisconsin. Following last week's defeat to Buffalo, the Dolphins QB is 0-4 in starts when the weather is below 50 degrees Fahrenheit; he is 17-7 when the temperature is at least 50 degrees.