Tennessee Titans coach Mike Vrabel says Derrick Henry is "willing and able to carry us" after another barnstorming performance in a thrilling 34-31 win over the Buffalo Bills in Monday Night Football.

Henry finished with 143 yards and three touchdowns as the Titans moved to 4-2 in the AFC South this season.

It marked the fifth straight game Henry surpassed 100 yards for rushing, while it is the third occasion this season he has ended with at least three touchdowns.

Henry joined Jim Brown (1958) as the only players in NFL history to rush for three-plus touchdowns in a game three times in the first six games of a season, according to Stats Perform.

Through Week 6, Henry has three games with 125 or more rushing yards and three-plus rushing touchdowns – it is tied for the most such games in a single season in the Super Bowl era.

Speaking after the game, Vrabel said of Henry: "We continue to jump on Derrick's back and he's willing and able to carry us. 

"It's something that you know you have in your back pocket, your front pocket and you can use it. He gave us a big shot right there."

For his part, Henry said he is just trying to perform his best for the team every time he takes to the field.

"I just love to come out here and try to be the best player and team-mate I can," he said. 

"Come out here and try to take advantage of my opportunities and make plays for this team. Whatever I can do to help us win, I am willing to do.

"This, today, was incredible. The whole atmosphere, it felt like a playoff game. The crowd was in it – they came and packed the stadium out. It's something that we'll always remember, especially on a big stage like this."