Derrick Henry came up big in the fourth quarter and the Tennessee Titans thwarted Josh Allen at the death in a thrilling 34-31 NFL victory over the Buffalo Bills.

Henry scored his third touchdown for the Titans (4-2) with just over three minutes remaining against the AFC East-leading Bills (4-2) on Monday.

The Titans then held up Bills signal-caller Allen on a fourth-down quarterback sneak in the final seconds to snap Buffalo's four-game winning streak.

Henry joined Jim Brown (1958) as the only players in NFL history to rush for three-plus touchdowns in a game three times in the first six games of a season, according to Stats Perform.

Through Week 6, Henry has three games with 125 or more rushing yards and three-plus rushing touchdowns – it is tied for the most such games in a single season in the Super Bowl era.

After a tense opening quarter – Tyler Bass' field goal for the Bills was the only score – Buffalo and Tennessee traded touchdowns in the second period.

Henry sparked the Titans with a memorable 76-yard TD run before Allen threw a 14-yard pass to Stefon Diggs just over three minutes later and the see-sawing battle continued – Allen's pass to Cole Beasley cancelled out Ryan Tannehill's (18-of-29 passing for 216 yards and an interception) four-yard run to give the Bills a 20-17 half-time lead.

Bass' third field goal and Allen's third TD pass (finishing 35 of 47 for 353 yards, three TDs and an interception) to Tommy Sweeney outweighed Henry's touchdown run as the Bills stretched their lead to 31-24 heading into the final period.

But Tennessee's defence came up big after Henry scored the only TD of the fourth quarter, having watched Randy Bullock convert his 38-yard field goal.