Deebo Samuel's season is in jeopardy after being carted off the field while his San Francisco 49ers led 21-0 in the first quarter of Sunday's game against the Tampa Bay Buccaneers.

Samuel, who was named First Team All-Pro last season, had already run for one of the 49ers' three touchdowns against the Buccaneers, but his fourth carry of the half resulted in a fumble as his knee got trapped and twisted under a mass of bodies.

He could not get back to his feet, requiring a medical cart to drive him back to the locker room, and there was no update before half-time.

Samuel entered the game with the second-most receiving yards on the team this season (569) and the fourth-most rushing yards (207), contributing five total touchdowns.

His absence thrusts Brandon Aiyuk to the top of the depth chart, however it remains to be seen if the 49ers will use him in the hybrid fashion of Samuel's unique role.

The 49ers reached the end of the first half with a 28-0 lead, with rookie quarterback Brocky Purdy throwing two touchdowns and rushing for one in the first start of his career.

Last week, the 49ers lost quarterback Jimmy Garoppolo to a near season-ending foot injury, with Trey Lance already sidelined with an ankle injury.