The Brooklyn Nets will be undermanned for Wednesday's blockbuster NBA matchup with Eastern Conference rivals the Philadelphia 76ers after Kevin Durant, LaMarcus Aldridge and Blake Griffin were ruled out.

Brooklyn and Philadelphia are set to do battle in a first-place showdown midweek – the two championship hopefuls share 37-17 win-loss records atop the east.

But the Nets will be without superstar Durant (hamstring – injury management) and former All-Stars Aldridge (illness – non-covid related) and Griffin (knee – injury management) as the trio join James Harden (hamstring) on the sidelines.

The star-studded Nets, however, do welcome back Kyrie Irving after he missed Tuesday's 127-97 rout of the Minnesota Timberwolves due to personal reasons.

Former MVP Durant was in doubt for the 76ers clash after playing 27 minutes against the Timberwolves.

Durant posted 31 points on 11-for-15 shooting in his third appearance following a 23-game injury absence.

The Nets-Timberwolves matchup was initially scheduled for Monday, but it was pushed back in the aftermath of Daunte Wright being shot and killed by a police officer in Minneapolis.

It meant Durant faced the prospect of back-to-back games, which the Nets opted to avoid as they eye their maiden NBA title.

Durant is averaging 28.2 points, 7.1 rebounds and 5.2 assists for the star-studded Nets this season.

He is also shooting a career-high 44.8 per cent from three-point range, while the two-time NBA champion (53.5) only boasted a better field-goal percentage in 2016-17 (53.7).