The Los Angeles Clippers' hopes of a deep playoffs run may have suffered a major blow after Paul George exited their 101-100 loss to the Oklahoma City Thunder with a leg injury.

George fell to the floor after his right knee collided with Luguentz Dort's knee in the air while attempting a rebound.

The eight-time All-Star got up with help and exited the game with 4:38 remaining in the fourth quarter.

Clippers head coach Tyronn Lue said during his post-game press conference that George was still being evaluated and that he had not spoken to him.

ESPN reported George was spotted exiting the arena in the back of a cart with his right leg extended.

George scored 18 points with seven rebounds, five assists and three steals before exiting, with the loss seeing the Clippers fall to a 38-35 record in fifth in the West.

The 32-year-old is averaging 23.9 points, 6.1 rebounds and 5.1 assists per game this season.

Team-mate Kawhi Leonard said the Clippers would take on a "next man up" mentality if George was unavailable for a significant period.

"Next man up, but we'll see," Leonard told reporters. "We've got a group of guys that still want to win and like to play basketball. We'll see happens."