Rilee Rossouw took the India attack apart with a stunning 48-ball century as South Africa secured a consolation 49-win Twenty20 International run victory.
After a pair of ducks in the opening two matches, Rossouw cracked 100 not out on Tuesday as the Proteas rattled to 227-3, before limiting the hosts to 178 all out at the Holkar Cricket Stadium in Indore.
India, armed with a 2-0 lead, were seeking to seal a series sweep ahead of three ODIs, but they did not threaten to get near South Africa's total.
South Africa opener Quinton de Kock made 68 from 43 deliveries and shared in a second-wicket stand of 90 with Rossouw, before the latter cut loose, with eight sixes in his maiden T20I ton.
India suffered a wretched start to their reply as they lost Rohit Sharma (0) and Shreyas Iyer (1) inside 10 balls.
From 4-2, they recovered somewhat, stepping up the run rate significantly, but Rishabh Pant (27) and Dinesh Karthik (46) had to keep going to make it competitive. Both were gone by the end of the seventh over, and so in essence was India's hope of victory.
India were seven wickets down by the time they got halfway to their target and a late flurry from the hosts serving essentially as crowd-pleasing batting practice. Lungi Ngidi took 2-51, in the process becoming the sixth South African bowler to reach 50 T20I wickets.
Dwaine Pretorius claimed 3-26 as the tourists finished the series on a high note.
Curious life of Rilee
Rossouw's ducks in the first two matches of this series were his third and fourth in T20Is, which is hardly ideal considering they were just his 18th and 19th innings in the short format. He has 12 sub-20 scores (including a 19no) in T20Is, but showed his class with a stunning century. It came as a mesmerising rate, with Rossouw topping his previous best of 96 not out, which came against England in Cardiff in July of this year.
A word, too, for De Kock, who passed the 2,000-run mark in T20Is, becoming the second player, after David Miller, to achieve that feat for the Proteas.
Twenty20 20 sets a record
Umesh Yadav's unbeaten knock of 20 was the highest individual score by an Indian batter coming in at number 10 or below in the batting order in men's T20Is. It made ostensibly no difference, but coach Rahul Dravid was seeking runs all the way down the order so would have taken that as a small positive.