Brathwaite returned figures of 4 for 18 that included the wickets of Chris Lynn, who top-scored with 56, the dangerous Joe Burns for 7, James Bazley for a duck and Mark Steketee for 2 as Brisbane were restricted to 148 all out.
Jake Ball took 3 for 25 from his too over to provide support to the giant Barbadian. Jackson Bird also weighed in with the ball taking 2 for 22.
Chasing 149 for victory, the Sixers were struggling at 54 for 4 before Captain Daniel Hughes’ 51 helped steady the ship. Hughes’s dismissal in the 17th created jitters for the Sixers. Brathwaite lost his wicket six balls later for just 2 as Sydney slipped to 130 for 6, which opened the door for Brisbane.
However, Daniel Christian’s unbeaten 38-ball 61 took the Sixers home, hitting the winning boundary off the final ball of the match with his side closing on 152 for 7.
The win put the Sixers on 25 points, two points clear of second-placed Sydney Thunder while the Hobart Hurricanes are third on 19 points.
Adam Zampa’s five-wicket haul was also instrumental to the Stars victory that moved them up to sixth in the Big Bash League table.
The Grenadian whose best score before Thursday was 18 against the Thunder on December 29, blasted an unbeaten 89 as the Stars racked up 179 for 2 in their 20 overs. The Spiceman smashed eight fours and four sixes in his 49-ball knock.
His 50 had come up from just 36 balls and included four fours and a six.
He featured in partnerships of 41 with fellow opener Marcus Stoinis (13); 61 with Glen Maxwell (39), and 77 with Hilton Cartwright, who remained unbeaten on 30 at the end.
Cameron Valente and Danny Briggs were the best of the Adelaide bowlers each returning figures of 1 for 36 from their respective four-over allotments.
Adelaide needing 180 to win, slumped to 68 all out in just 14.2 overs as Zampa took 5 for 17, Glen Maxwell, 2-12 and Zahir Khan 2-19 to seal the comprehensive victory.
Matt Renshaw (20), Johnathan Wells (18) and Jake Weatherald (10) were the only Adelaide batsmen to get to double figures.
Hosein took three wickets and scored a quick-fire 30 for Melbourne after Russell had bludgeoned them back into contention after a Michael Neser’s hat-trick had threatened to deny them victory.
Brisbane won the toss and chose to bat first but were two wickets down for 14 in the third over thanks to Mujeeb ur Rahman and Hosein who claimed the wickets of Max Bryant for five and Colin Munro for eight, respectively.
However, knocks of 25 from Sam Billings, 29 from Matt Renshaw and an unbeaten Jimmy Peirson helped stage a recovery. However, after a partnership of 61 between Billings and Renshaw both were dismissed by Tom Rogers in the 11th over as Brisbane slipped to 78-4.
It was soon 96-5 as Rogers dismissed Ross Whitely for 8 in the 15 over.
Hosein took the wickets of Neser (3) and James Bazley (0) in three balls in the 15th over. Peirson smashed 45 from 30 balls with six fours to get Brisbane to a competitive 138-7.
Rogers ended with 4-23 while Hosein took 3-26 in another solid performance with the ball.
Melbourne’s relatively simple chase of just under seven runs an over, became extremely difficult when Neser ripped through the top order with just nine runs on the board.
He dismissed Sam Harper first ball and then Jake Fraser-McGurk from the final ball of the first over and then in his second dismissed Nic Maddinson for two and Johnathan Wells for a duck in consecutive balls of his second over to leave Melbourne facing defeat.
However, Russell and Aaron Finch staged a recovery would set the team firmly on the path to victory.
Russell hit two fours and six sixes and he and Finch put on 81 for the fifth wicket before he got out caught behind off Mark Steketee for 57 from 42 balls.
Hosein picked up from where Russell left off hitting two fours and two sixes in a 39-run partnership with Finch. He eventually holed out to deep midwicket for 30 from 19 balls off the fifth ball of Steketee’s final over with Melbourne needing just nine from seven balls.
Will Sutherland smashed Steketee’s last ball for a massive six over the midwicket boundary leaving Finch to hit the winning runs, a four over extra cover to seal with victory from Bazley’s second ball of the final over.
Melbourne’s third straight win means they have six points and only trail leaders Adelaide Strikers on net run rate.
