Wales boss Warren Gatland has made seven changes to the starting line-up for Saturday’s Guinness Six Nations clash against England at Twickenham.

Centre George North returns from injury for his 50th Six Nations appearances, lining up alongside Nick Tompkins in midfield.

Fly-half Sam Costelow, who went off injured during the first-half of Wales’ 27-26 loss to Scotland last weekend, is replaced by Ioan Lloyd, with Tomos Williams at scrum-half.

Gatland has also selected a new front-row of Gareth Thomas, Elliot Dee and Keiron Assiratti, with Cardiff flanker Alex Mann handed a first Wales start following his try-scoring appearance off the bench against Scotland.

Owen Watkin will complete an impressive recovery from World Cup reject to Six Nations starter when Wales tackle Scotland on Saturday.

Wales head coach Warren Gatland selected seven centres as part of an expanded training squad in May last year for the World Cup – but Watkin was not among them.

George North, Mason Grady, Nick Tompkins, Joe Roberts, Johnny Williams, Max Llewellyn and Keiran Williams were Gatland’s preferred options, with 27-year-old Watkin left in the wilderness.

“Being left out of the training squad was really heartbreaking and massively disappointing for me,” he said.

“But I think setbacks like that can motivate you even more. I didn’t let it get the better of me.

“I knew I had to put more work in, stay injury-free and just create that momentum. I feel confident at the minute, I feel like my game is going well.

“I am probably being a bit braver with things I am trying, I am probably not just going through the motions.

“I am enjoying my rugby at the Ospreys, we are scoring some nice tries and winning some really tough games. I want to bring that momentum from there and try and implement it with Wales.”

While Watkin has won 36 caps and is the sixth-most experienced player in Wales’ starting line-up this weekend, it is his first Test appearance since an ignominious home defeat against Georgia during the 2022 autumn Tests.

“Obviously, you don’t want to go out on a loss,” Watkin added. “I did have that fear of ‘what if it was my last game for Wales’.

“I think I’ve put the work in and I do deserve to be back and I am focusing on the Scotland game. The Georgia game is behind me – I don’t even think about that now.”

Watkin will forge Wales’ midfield partnership with Nick Tompkins, offering an experienced combination as Wales look to make it 12 games unbeaten in Cardiff against Scotland.

The last time Scotland triumphed in the Welsh capital, current head coach Gregor Townsend was fly-half and it required injury-time penalties from Brendan Laney and Duncan Hodge to secure a 27-22 win.

Wales, though, have got it all to do this time around, underlined by a line-up that contains their lowest cap total for a Six Nations game since facing Italy five years ago.

Watkin added: “We know that they (Scotland) are a great team, they can turn it on when they are on their day and we know it is going to be a huge physical battle out there.

“It is going to be high intensity but like I said, we just need to focus on ourselves and control what we can control.

“We want to play rugby, but you have obviously got to play in the right areas.

“You can’t go playing from anywhere, against a team like Scotland as well, (because) they will punish you.

“It’s just (being) sensible where you play from, but when we get the opportunities we are going to look to play.”

George North says he is not contemplating following the likes of fellow Wales stars Leigh Halfpenny and Dan Biggar into international retirement.

Halfpenny, Alun Wyn Jones and Justin Tipuric are the centre of attention when Wales face Principality Stadium opponents the Barbarians on Saturday.

Jones, who made a world record 158 Test match appearances for Wales, captains a Barbarians team that features 93 times-capped flanker Tipuric among his colleagues.

And full-back Halfpenny, with 101 caps under his belt, is set for a final Wales outing before moving to the southern hemisphere, where he is expected to join Super Rugby giants the Crusaders.

Fly-half Biggar, meanwhile, left the international stage following Wales’ World Cup campaign in France and continues to play for Top 14 club Toulon.

At 31, centre North can reflect on a Wales career that has yielded 118 caps and 47 tries, but his appetite for more remains firmly intact.

“I felt like I was really happy with my performance in the World Cup,” said North, who will partner Johnny Williams in Wales’ midfield this weekend.

“(I am) still competing, so for me, I am very much still wanting to play and compete for that jersey. It is still a huge part of me and a big driver for me.

“If the boss (Wales head coach Warren Gatland) keeps picking me, I will keep doing the best I can.

“It is obviously a sad day to be losing them. They are big characters and big players for us and have delivered on numerous occasions in big games that people still talk about now.

“But that is the evolution of rugby and you have got to keep up with the curve.

“I think we saw in the World Cup a number of younger players putting their hands up and taking a step forward. It is time for these boys to get that exposure and get into Test match rugby.”

North, meanwhile, has paid glowing tributes to Jones, Tipuric and Halfpenny as he prepares to share a big-match stage with them for a final time.

“Al is a guy I’ve known for many years and played alongside,” he added.

“He is an absolute Trojan horse, what he has given to Welsh rugby over the, what is it, 25-30 years he has been playing! For Al to have his last game at home, playing against Wales, is special for him.

“I think Justin is probably one of the best players I’ve played with, his understanding of the game, how best to apply himself and one of the fittest players.

“He could play anywhere. Some people say he could play from full-back to back-row and I am sure he could do a better job than most of us.

“Leigh is another awesome servant of Welsh rugby, a close friend of mine and a brother in arms.

“He literally leaves no stone unturned and he goes out of his way to help anyone and everyone. For Leigh to finish at home is special for him and his family and he has got an exciting next step as well.”

Warren Gatland says it would be “a huge achievement” if Wales reach their third Rugby World Cup semi-final in the last four tournaments by beating Argentina on Saturday.

Gatland’s team face the Pumas in Marseille after dominating a pool that some thought they might not qualify from following a dismal Six Nations campaign last season.

Four successive wins and 19 points collected saw them leave sides like Fiji and Australia in their slipstream to set up the Pumas clash at Stade Velodrome.

“It would be our third semi-final, and then in 2015 we were leading South Africa for 75 minutes (in the quarter-finals) and conceded at the end,” Gatland said. “Reflecting on that, we would be pretty proud.

“I have always spoken about how much I have enjoyed the World Cup preparations.

“It is the only time you get to feel like you are a club side in getting that detail done. You feel like you have made a huge amount of progress.

“After all the challenges during the Six Nations, with the potential (player) strike and the contracts and the money with the Union (Welsh Rugby Union) and regions, as coaches we would joke about what would happen next, what would be the next thing thrown at us?.

“I definitely think there has been a line in the sand drawn under that. If we can make the semi-final it would be a huge achievement for this group of players and coaches, who have done a great job, and the back-room staff have been outstanding.

“I know there are some people and some teams out there who won’t want to face a Wales team when they start playing with confidence and when we start having momentum.

“That is when we are at our most dangerous. We are starting to look that way at the moment.”

Wales have not met Argentina in the World Cup for 24 years, but their recent form against them is impressive, having lost just two of the last 11 Tests.

And while Wales sailed through their group, Argentina lost to 14-man England, unconvincingly beat Samoa and then defeated Japan in what was a quarter-final eliminator.

Gatland added: “We are expecting them to come really hard at us. I don’t think anything changes, and the players are well aware of that.

“We talk about being on the edge mentally and you can’t be there at the top of that every single week, so it is how close you can get to it.

“We’ve had a couple of games already where we feel we have been really on the edge in a positive way, and a couple of games where we have been off two or three per cent, so it is how close you can get to that 100 per cent mental peak.

“I am expecting that will be right up there from that physical challenge that will come at us.”

Wales show one change from the side that beat Fiji and Australia, with Tommy Reffell called up to the back-row and Aaron Wainwright switching from blindside flanker to number eight instead of broken arm victim Taulupe Faletau.

Centre George North, meanwhile, will become the first Wales player to feature in four World Cup quarter-finals.

“It is an unbelievable achievement, especially when you realise it after how much hard work all of the boys in every team have to do for a World Cup – it is years in the undertaking,” North’s midfield partner, Nick Tompkins, said.

“So, for him to do it four times is pretty impressive. I am not sure I would be able to do that.

“It speaks volumes for the determination and kind of bloke he is. He is on the best form he has been on for a long, long time.”

Wales centre George North will join an elite Rugby World Cup club when he runs out against opening opponents Fiji on Sunday.

It will be North’s fourth tournament, a feat achieved by only four other Welshmen in Gethin Jenkins, Alun Wyn Jones, Gareth Thomas and Stephen Jones.

And, at 31, he is showing no sign of slowing down, remaining a pivotal figure in head coach Warren Gatland’s plans.

With 114 caps, North is the most experienced Wales player on show at France 2023, underlining his consistency, durability and quality.

“I hoped that I would get to one (World Cup), for sure. To represent your country is huge, but to play at a World Cup is wicked,” he said.

“I am still fighting and competing, and find myself at number four.

“I guess it’s just a kudos to myself and shows all the work you put in is worth it to get to a fourth. I am still enjoying it.”

North is enthused by Wales’ current World Cup crop, with the squad featuring 16 tournament debutants, including co-captains Jac Morgan and Dewi Lake.

He also has three other cap centurions for company in Dan Biggar, Taulupe Faletau and Leigh Halfpenny as Wales look to make an impact in France.

It will be Gatland’s fourth World Cup at the Wales helm, having previously masterminded two semi-final appearances, and North has been there every step of the way.

He also believes Gatland has firmly put his stamp on the squad, nine months back into his second stint as Wales boss and following a difficult Six Nations campaign last season.

“The vibe has been really good,” North added. “For a lot of the boys it is their first World Cup, so they are going into the unknown and they are excited.

“I think everyone has just bought into it straight off, and I think that comes from ‘Gats’ when he set the tone with his last message from the Six Nations to the first day in World Cup camp – ‘this is how we are going to do it, this is how I want to do it. You either want to be in, or you don’t’.

“Some of the (training) sessions in Switzerland were brutal, probably some of the hardest I have ever done. The same in Turkey.

“We came off the paddock and we had knocked lumps out of each other for 40-odd minutes in 46 degrees. It’s all about his way of building that resilience, building that robustness into the squad.

“He pretty much said to us after we played France in the last round of the Six Nations that the World Cup was going to be the hardest thing you will ever do. He was not lying.”

Wales find themselves in a World Cup pool alongside three of their opponents from Japan four years ago – Fiji, Australia and Georgia – with North underlining the importance of a strong start.

“We need to start with a win on Sunday, pure and simple,” he said.

“The squad is in a really good place. Everyone understands where we are, everyone is well drilled on how we want to go about our work.

“The training camps we have been on have been brutal, absolutely brutal. The default setting is never give in, keep moving, keep going, keep going, keep going.”

George North is looking forward to the day his children face the big choice: cycling or rugby.

North is also looking forward to the Six Nations Championship, starting this weekend, when Wales begin their title defence against Ireland in Dublin.

There is an awful lot for this 29-year-old to be looking forward to, now that his injury hell has passed.

For now, North is enjoying the freedom of being able to run again, after suffering an anterior crucial ligament (ACL) injury in his right knee last April, playing for the Ospreys.

It ended his year on the rugby pitch, ruining hopes of a starring role for the British and Irish Lions in South Africa and denying him a shot at the Springboks, Australia and New Zealand in the autumn internationals.

North would sooner have been healthy and active of course, but being sidelined has had its upsides. He and his wife, double Olympic cyclist silver medallist Becky James, welcomed their second son, Tomi, a brother for Jac, in October.

Rather than dividing his time between the family and Wales camps, North has been essentially a stay-at-home dad for months on end.

"It's been brilliant. Normally I'm away playing or touring or something," says North, who is a Land Rover ambassador.

"To have this time at home, it's priceless. But Becky's been a superstar. When I had my surgery to start with, I couldn't do much on crutches with Jac, and obviously Tomi's joined us now and he's class.

"I'm in that stage now where effectively I'm in pre-season again, and I'm absolutely battered when I come home from training. And I'm not much use to anyone, but she's been amazing through this whole process.

"It has been tough, but it's been amazing you know, the two boys are amazing. Thank goodness for Becky, because it'd have been a lot harder at one point, with one leg up and hopping around the place. Especially my surgery, it was very tough. But yeah, she's a superhero."

Wales have been Six Nations champions four times in the last 10 years. Despite being holders, however, few are giving them much of a chance this time around.

After all, Wales have been up and down with results in the tournament. Across the last five years, they have trailed in fifth twice, as well as clinching a couple of championships, including the 2019 grand slam.

This time, they head into the tournament without a clutch of key players: North is absent, but so too is captain Alun Wyn Jones, with Taulupe Faletau, Leigh Halfpenny, Josh Navidi, Ken Owens and Justin Tipuric also sidelined.

Head coach Wayne Pivac said his squad has lost around 680 caps' worth of experience, but Wales should still be no mugs.

The players Pivac has chosen for the tournament come with an average of 27.1 Test caps of experience, only topped by Ireland's 30.9 among the six teams.

Those that are missing are proven class, however. In last year's championship, Faletau had 66 carries, putting him in third place among all players, while Tipuric made the most tackles (82). Faletau was fourth on that list (74), and skipper Jones was sixth (72).

On the Six Nations all-time list, North, who has featured on the wing and at outside centre, ranks fourth for metres gained (2,548), third for defenders beaten (126), and third for most clean breaks (48).

Jones is top of the all-time tackles chart (719), with fly-half Dan  Biggar a different animal to the absent lock. Biggar sits second on the Six Nations' all-time try assists list, after setting up 17 five-pointers in the competition.

To lose a raft of proven top-level talent would hurt any team, and North is not blind to that. He has been in and around the Wales squad since his late teens, however, so is certain there will be no defeatist attitude in Pivac's camp.

"Obviously there are a number of players out missing, and I think Wayne's come out with a stat of something like 680 caps that he's lost," says North. "That's a tough place to be."

But can Wales kick on regardless? North says so.

"Well, that that's the only way you get better, isn't it? By pushing the standards up every time," North tells Stats Perform News.

"I think for us, as Wales, we're used to being the underdogs, and we're always used to being kind of like always wanting more, and I think that shows in the performances that we have and the results we have had of late.

"From the lads' point of view, that's something they will certainly be looking at: how they push on from last year. Obviously winning the championship [is one thing], but you know the next step is backing it up again and as we said, it's going to be incredibly tough for the boys."

In the 2021 Six Nations, Wales made the most tackles of all teams (871), were third for tackle success with a healthy 88.2 per cent record, ranked second for lineout success with 90.8 per cent, and matched France for the most scrum success with 96.2 per cent.

Pivac's side averaged 3.7 points per entry into the opposition 22, making them the only side to average over three points per entry. It is a hard act to follow.

The loss of veteran skipper Jones gives 32-year-old playmaker Biggar the opportunity to lead the team into the championship.

"Yeah, it's not easy following the most capped player in the world is it!" North says. "I wouldn't like to follow Alun Wyn, put it that way.

"But what you're getting with Dan is a fierce competitor who drives the squad from the front row, right the way back all the way through to the full-back.

"He expects high standards of everyone, and he expects those standards of himself. I'm excited to see Dan as captain because what you see on the field is a fierce competitor. And that's not just on the field, that's Monday to Friday, and that's in whatever jersey he is.

"He expects the best for himself, and also the best from others because you know he is a competitor and wants to win."

North has the most international tries of all current players in the world game, and he has spoken of hoping to be available to Pivac at the back end of the championship.  Wales have home games against France and Italy on March 11 and 19 to finish the campaign.

He longs to make his children proud, even though both are much too young to understand his day job, or to understand their mother was a world champion.

From the routines of parenthood to the cauldron of the Principality Stadium, North is focused on pulling out all the stops. Jac and Tomi are keeping him grounded but also fuelling his ambitions.

"Obviously they don't know what Dad does. They don't know what Mum used to do," he says. "And I think that's something that's special.

"I am looking forward to the day that I'd be able to play and Becky can bring the boys to watch. I'm incredibly proud and honoured to be able to play rugby, but to be able to share that with the boys and, you know, show them more. Whatever they want to do in the future, there's always that conversation, is it a bike or a rugby ball?"

North, who during last year's Six Nations became the youngest player to reach 100 caps for any country, is targeting the 2023 Rugby World Cup as a long-range goal.

That could add up to over two months away from home, and given he will be 31 by the time that tournament comes around, it might be a last shot at global glory.

"I've got a fair few steps to cross off before we get back in any jersey. Certainly it's something I want to be able to put my hand up and be fighting for my selection there," he says.

"I've been very fortunate to go to a few now, and you know that's a big push. It's not too far away, and it's something that is certainly exciting."

There he goes again, always looking forward.

:: George North is a Land Rover ambassador. Visit landrover.co.uk

George North still believes he could feature for Wales at the back end of the Six Nations as he prepares to return from a gruelling knee injury lay-off.

The star back, who has successfully converted from wing to outside centre with Wales, has the most international tries of all current players in the world game.

However, an anterior crucial ligament (ACL) blow has put his career on hold. Sustaining the injury last April forced North to miss the British and Irish Lions' tour of South Africa, plus the autumn internationals.

He was not included in Wales' 36-player squad for the Six Nations this week, absent along with several other notable injury casualties, including captain Alun Wyn Jones.

Champions Wales start their Six Nations defence against Ireland in Dublin on February 5, a date which has come much too soon for North to be considered. His short-term priority is getting in shape with his club side, the Ospreys.

"Hopefully I'll be back into some sort of team training next week," North told Stats Perform.

Asked whether there was any hope of him being available to Wales during the championship, North said: "There's two big steps: getting back to training full time with the Ospreys, then playing for the Ospreys with a view to potentially, maybe, catching the end of it.

"But at the moment I'm just focusing on playing back for the Ospreys."

Wales have home games against France and Italy on March 11 and 19 to finish the campaign, and North may be pushing for selection by then.

He has been a key component of the Wales team since making his debut as a teenager, and passed 100 caps during the Six Nations last year.

The 29-year-old has been itching to get back into action, but his absence from the pitch has allowed North some valuable family time.

He married Olympic cyclist Becky James in 2019, and they had a second son, Tomi, in October of last year.

North describes his wife as "a superstar" for helping him through a difficult rehabilitation period, and the former Northampton and Scarlets star is relishing his return to action.

"I take great confidence in knowing a load of rugby boys that I know have had single or double ACLs and they're still playing now, with no issues," North said.

"Luckily, I'm in a good generation where the medical care is advancing so quickly, so I'm benefiting from that. For me now, the focus is just to get back.

North, who is a Land Rover ambassador, is evidently relieved to be finally "on the home straight", as he puts it. He compares his current routine to that of a demanding pre-season, with full contact training still to come.

"I'm finding already this is the most frustrating part," he said, "because obviously you're a lot closer than you were six months ago."

He can only encourage his Wales colleagues from a distance as the Six Nations looms, and with the likes of Taulupe Faletau, Leigh Halfpenny, Josh Navidi, Ken Owens and Justin Tipuric also sidelined, it will be a challenging campaign for coach Wayne Pivac. North prefers to look at the positives that might come from this testing time.

"With adversity, you get exciting results," said North, "and the younger boys coming through that we've picked are exciting boys, and I'm excited to see how the boys come together to push on.

"Any Six Nations is tough. Obviously, you want your main team out there the best you can, and injuries are a nightmare for any team."

:: George North is a Land Rover ambassador. Visit landrover.co.uk

George North will miss the British and Irish Lions tour of South Africa after suffering a serious knee injury.

The versatile Wales back on Wednesday confirmed he sustained a ruptured anterior cruciate ligament in the Ospreys' Pro14 Rainbow Cup win over Cardiff Blues on Saturday.

North will undergo surgery next week and could be out for up to nine months, ruling him out of contention for what could have been his third Lions tour.

The 29-year-old tweeted: "Sport can be cruel. We all know the risks when we take the field.

"Unfortunately I ruptured my ACL on Saturday and will need surgery next week. Heartbroken is an understatement."

Wales go in search of a Triple Crown in a blockbuster battle against England, but France will not have an opportunity to make it three Six Nations wins out of three this weekend.

Wayne Pivac's Wales side are level on nine points with Les Bleus following victories over Ireland and Scotland, both of whom had a man sent off.

George North will become the youngest player in history to win 100 caps, but defending champions England will be determined to spoil the Wales centre's big occasion at the Principality Stadium on Saturday.

The Red Rose beat Italy 41-18 last time out, following a loss to Scotland at Twickenham.

Winless Ireland will be expected to defeat the Azzurri to get up and running in the opening match of round three at Stadio Olimpico.

Sunday's planned showdown between France and Scotland was postponed due to a COVID-19 outbreak in the French squad.

We preview the matches in Rome and Cardiff with help from Opta.

ITALY v IRELAND

FORM

Ireland have scored 45 tries across their last seven games against Italy in the Six Nations (6.4 per game), scoring eight or more tries in three of their last five clashes.

Italy have conceded a try-scoring bonus point in 17 of their 22 matches since those incentives were introduced to the Six Nations in 2017; only England (9) have picked up more bonus points in the championship than Ireland (8). The Azzurri are the only side yet to register one.

Ireland have lost their opening two games of a Six Nations campaign for the first time. The last time they lost their opening three matches was in 1998, when they were beaten in all four Five Nations clashes.

ONES TO WATCH

Sebastian Negri has made 96 metres and made 21 tackles combined in Italy's losses to France and England. Franco Smith will need another strong showing from the flanker.

Ireland back-row CJ Stander has made more carries (36) than any other player in the 2021 Six Nations. He has topped the final rankings for this category in three of the last four editions of the championship.

WALES v ENGLAND

FORM

England have won six of their last seven Six Nations matches against Wales, with the last six of those fixtures all decided by a single-figure margin.

Wales have won their opening two games of the tournament for a sixth time. On four of the previous five occasions when they have started with back-to-back victories, they have gone on to win a Grand Slam (2005, 2008, 2012, 2019, not in 2009).

This weekend's visitors are the only team to have never conceded more than two tries in a Six Nations game played in Wales. They have scored 19 tries in Wales during the Six Nations, no visiting team have scored more (Ireland also 19).

ONES TO WATCH

North will become only the sixth Wales player to win a century of caps. The 28-year-old will form a new pairing with Jonathan Davies and will be looking to bring up his hundred with an all-action display.

Elliot Daly will win his 50th cap for England and coach Eddie Jones will expect the full-back to repay the faith he has shown in him after a slow start to the tournament.

George North will become the youngest player in world rugby to reach 100 caps after being named in Wales' starting line-up for Saturday's Six Nations showdown with England.

The 28-year-old, who won his first cap in November 2010, returns to the side at outside centre as one of five changes from the 25-24 win over Scotland on February 13.

Wing Josh Adams is back from suspension while Josh Navidi, Jonathan Davies and scrum-half Kieran Hardy are also included in the XV, the latter making his first Six Nations start.

Wales have won their opening two games in this year's tournament and are three points ahead of England, who beat Italy 41-18 last time out after losing to Scotland in their opener.

Eddie Jones makes two changes to the England line-up, with hooker Jamie George and flanker Mark Wilson replacing Luke Cowan-Dickie and the injured Courtney Lawes respectively.

Elliot Daly retains his place and is set to win his 50th cap for England, who have named the uncapped George Martin among their replacements for the Principality Stadium clash. 

"We know we'll be up against a strong Welsh challenge on Saturday, but we've worked really hard in training this week and have got a very good team to face it," Jones said.

"We want to show people what we are capable of, keep building our performances and show the best is yet to come from this England team."

Wales XV: Liam Williams; Louis Rees-Zammit, George North, Jonathan Davies, Josh Adams; Dan Biggar, Kieran Hardy; Wyn Jones, Ken Owens, Tomas Francis, Adam Beard, Alun Wyn Jones, Josh Navidi, Justin Tipuric, Taulupe Faletau.

Replacements: Elliot Dee, Rhodri Jones, Leon Brown, Cory Hill, James Botham, Gareth Davies, Callum Sheedy, Uilisi Halaholo.

England XV: Elliot Daly, Anthony Watson, Henry Slade, Owen Farrell, Jonny May, George Ford, Ben Youngs; Mako Vunipola, Jamie George, Kyle Sinckler, Maro Itoje, Jonny Hill, Mark Wilson, Tom Curry, Billy Vunipola.

Replacements: Luke Cowan-Dickie, Ellis Genge, Will Stuart, Charlie Ewels, George Martin, Ben Earl, Dan Robson, Max Malins.