Daniil Medvedev was defeated on his ATP Tour return at the Geneva Open by a sparkling Richard Gasquet, a blow to the Russian ahead of the French Open

World number two Medvedev was making his first appearance since March after undergoing a hernia operation and fell to a 6-2 7-6 (7-5) defeat.

The Russian's rustiness was clear in the last-16 tussle as he racked up seven double faults and struggled to make inroads on Gasquet's second serve, with the Frenchman winning 61 per cent of points behind it.

It was the first time Gasquet overcame an opponent ranked in the top two since beating Roger Federer at the 2005 Monte Carlo Masters.

Next up for Gasquet will be Kamil Majchrzak, who beat Marco Cecchinato 6-2 6-3.

At the last-32 stage, Fabio Fognini went down 6-4 6-3 to Thanasi Kokkinakis and Albert Ramos-Vinolas succumbed to a 7-6 (7-5) 6-4 loss against Christopher O'Connell.

Johan Nikles, Nikoloz Basilashvili and Joao Sousa also advanced to the second round.

Top seed Cameron Norrie cruised into the quarter-finals of the Lyon Open by beating Francisco Cerundolo 6-4 6-4.

The Briton will face another Argentinian next in the form of Sebastian Baez, who came from a set down to beat Oscar Otte 5-7 6-4 6-2. 

Alex De Minaur also had to rally for a 1-6 6-3 6-2 win against Ugo Humbert, with Yosuke Watanuki awaiting in the last eight after the world number 263 beat Soonwoo Kwon 6-3 6-4.