Hugo Gaston fought back from a set down to beat Jan-Lennard Struff at the Grand Prix Hassan II.
Gaston rallied after dropping serve twice in the opening set, prevailing 3-6 6-4 7-5 to become the first player to book their spot in the last-16.
Jaume Munar followed suit with a 6-4 6-4 victory over Elliot Benchetrit.
Elsewhere, at the Estoril Open, victories for Pedro Cachin and Sebastian Baez set up a potential hat-trick of wins for Argentine players.
Cachin beat Tseng Chun-hsin 6-4 6-4 and Baez overcame Radu Albot 7-5 7-6 (7-3) but seventh seed Diego Schwartzman could not follow up with a win of his own, losing 6-3 7-6 (10-8) to Marco Cecchinato.
Fabio Fognini also booked his spot in the last 16 by beating compatriot Alessandro Giannessi in straight sets.