Novak Djokovic will not feature at the Indian Wells Open.
It was confirmed by tournament organisers on Sunday that the world number one would miss the first Masters 1000 tournament of the season.
As he is not vaccinated against COVID-19, Djokovic had applied for special permission to enter the United States, but that has seemingly been denied.
Until at least April 10, international visitors to the US must have proof of vaccination.
Djokovic, a five-time winner at Indian Wells, is also set to miss the Miami Open later in March, while his participation in the US Open could be in doubt.
The 22-time grand slam champion – who reached the semi-finals at the Dubai Tennis Championships last week – missed last year's major at Flushing Meadows due to his vaccination status. He was, however, allowed to play in this season's Australian Open.
Nikoloz Basilashvili moved into the main field following Djokovic's withdrawal.