Russell Wilson was central to the game-winning drive as Melvin Gordon III went from zero to hero with a late touchdown as the Denver Broncos edged the San Francisco 49ers 11-10 in Sunday Night Football.

Gordon atoned for two fumbles with a one-yard touchdown run with 4:10 remaining, capping a 12-play, 80-yard drive for the Broncos' only TD of the game.

Denver QB Russell Wilson completed 20 of 33 attempts for 184 yards with no touchdowns or interceptions, with a dart to Kendall Hilton in the game-winning drive. The Broncos went three-and-out nine times, yet still won to improve to 2-1.

Kareem Jackson recovered Jeff Wilson Jr's fumble with 1:05 to secure the victory as 49ers stand-in QB Jimmy Garoppolo tried to drive his side within field-goal range.

Garoppolo, making his first start of the season with Trey Lance out with a season-ending ankle injury, had one touchdown pass on 18-for-29 passing for 211 yards, with one interception. He also gave away a self-inflicted safety in the third quarter, helping the Broncos cut the deficit to 7-5.

The 49ers, who lost left tackle Trent Williams to an ankle injury, had gone ahead in the first quarter when Garoppolo found Brandon Aiyuk with a three-yard strike.

Robbie Gould's fourth-quarter field goal padded the 49ers lead out to 10-5, but Wilson was clutch late, leading to Gordon's TD.