The Philadelphia Eagles completed an epic comeback in the final minute as the Carson Wentz-led team stunned the New York Giants 22-21.

With 40 seconds remaining and Philadelphia starring at a fifth defeat of the NFL season, Wentz threw an 18-yard touchdown pass to running back Boston Scott to lift the rallying Eagles – who trailed 21-10 with just over six minutes left to play on Thursday.

Wentz was the instigator for the injury-hit Eagles (2-4-1), leading a pair of touchdown drives in the fourth quarter as Philadelphia moved into the driver's seat in the NFC East.

Eagles quarterback Wentz finished 25-of-43 for 359 yards, three touchdowns and an interception in Philadelphia, where the Eagles extended their winning streak over rivals the Giants (1-6) to eight games.

Brandon Graham sealed the victory by strip sacking Daniel Jones – who was 20-of-30 for 187 yards, two touchdowns, an interception and three sacks – forcing the Giants' third turnover of the game.

Jones made a dazzling 80-yard run – the longest by a quarterback in Giants history – but he tripped with no one around him and ended up eight yards short of the end zone. New York, though, managed a TD on that drive via Wayne Gallman.

The Eagles and Giants traded touchdowns in the opening quarter – Wentz' one-yard run cancelled out by Jones' 30-yard pass to former Philadelphia wide receiver Golden Tate.

A Jake Elliott field goal for the Eagles was all that separated the teams before New York took control – Gallman's third-quarter run giving the visitors a 14-10 lead.

Jones' second TD pass, this time finding Sterling Shepard, had the Giants in the box seat before Wentz inspired Philadelphia's late fightback.