Adrian Peterson and Le'Veon Bell will swap the pads and helmets for gloves and shorts after agreeing to meet in an exhibition boxing match later this month.
The veteran running backs are due to face off in the squared circle at Los Angeles' Crypto.com Arena on July 30.
Bell, a three-time Pro Bowler, made the announcement on social media.
"[And] it's official nothing else needs to be said, let's gooo," Bell, 30, posted on Twitter, accompanied with a poster promoting the bout.
Peterson is not officially retired from the NFL but made just four appearances for the Tennessee Titans and Seattle Seahawks in the 2021 season.
The 37-year-old became a star name during a 10-year stint with the Minnesota Vikings and was named MVP in 2012 - a campaign where he became the seventh player to rush for 2,000 yards in a season.
Peterson ranks fifth on the NFL's career rushing yards list with 14,918 and is a seven-time Pro Bowler.
Like Peterson, Bell has not officially hung up the cleats but has struggled to find a permanent home since leaving the Pittsburgh Steelers in 2018. Last season, he made eight appearances for the Baltimore Ravens and Tampa Bay Buccaneers.
ESPN reported the fight will take place on the undercard of Social Gloves 2, an event promoted by YouTube star Austin McBroom.