Kyler Murray made NFL history after combining with DeAndre Hopkins for an incredible game-winning touchdown for the Arizona Cardinals against the Buffalo Bills.

Murray's 43-yard pass was brilliantly caught by Hopkins in the endzone with two seconds remaining to secure a win for the Cardinals on Sunday.

The top pick in the 2019 NFL Draft, Murray's throw to Hopkins was his only touchdown pass, as he finished 22 of 32 for 245 yards.

But he rushed for two scores, tallying 61 yards on 11 carries, as the Cardinals improved to 6-3.

According to Stats Perform, Murray became the first player in NFL history with a pass TD and a rush TD in five straight games, thanks to his pass to Hopkins.

Murray also joined Cam Newton as the only QBs in NFL history with 6,000-plus pass yards and 1,000-plus rush yards in their first 25 career games, as per NFL Research.

The Cardinals trailed 23-9 against the Bills early in the third quarter before scoring 17 unanswered points.

But Josh Allen and Stefon Diggs combined for 21 yards with 34 seconds left to give Buffalo (7-3) a lead, and seemingly victory, before Murray and Hopkins delivered a game-winning play.

The Cardinals moved top of the NFC West, with the Los Angeles Rams and Seattle Seahawks also holding 6-3 records, while the Bills top the AFC East.