Atlanta Falcons quarterback Matt Ryan insisted the team's Super Bowl LI meltdown has "no bearing" on Sunday's NFL clash with Tom Brady's Tampa Bay Buccaneers.

Brady was part of the New England Patriots team that completed the largest comeback in Super Bowl history after rallying past the Falcons in 2017.

Ryan's Falcons surrendered a 28-3 lead as the Patriots sensationally prevailed 34-28 in overtime.

Falcons veteran Ryan will do battle against Brady, who now wears a Buccaneers jersey after leading Tampa Bay to the Super Bowl last season.

But that Super Bowl collapse is not in Ryan's head, with the 36-year-old – who is 0-5 against Brady in his career – discussing the infamous defeat on Wednesday.

"I haven't," Ryan said when he heard a reference to the Super Bowl LI loss. "I never heard of it."

The Falcons lost 32-6 to the Philadelphia Eagles in Week 1 after Ryan (21-of-35 passing for 164 yards) did not throw a touchdown.

Ryan threw for 164 yards, his fewest in a game since Week 7 of 2019 (159) and his second fewest to open a season in his career, behind only the 161 yards in his first career game in 2008, per Stats Perform.

It was Atlanta's worst loss to open a season since losing by 38 in their opening game in 1987. The Falcons made field goals on each of their first two drives and then either punted or had a turnover on downs in each drive after that.

"Of course we want to win. It's not going to make up for that," Ryan said, discussing the Super Bowl defeat to the Patriots. "You know, it's one of those things. It's part of your past, it's part of what happened.

"But it's got no bearing on this week."