The defending Super Bowl-champion Kansas City Chiefs open the 2023 NFL season against the Detroit Lions on Thursday, and it's uncertain if All-Pro tight end Travis Kelce will be able to play.

Kelce hyperextended his knee during Tuesday's practice, putting his status in doubt for Week 1.

Chiefs coach Andy Reid did not provide any details about how the injury occurred during Kansas City's final practice ahead of the season opener.

Kelce has not missed a game to injury since his 2013 rookie season and has been indispensable to Kansas City's offense as Patrick Mahomes' favourite target.

Near the goal line, he is Mahomes' go-to receiver, as no player was targeted more in the red zone last season than Kelce with 30.

Widely considered the top tight end in the NFL, the 33-year-old caught a career-high 110 passes for 1,338 yards in 2022, his seventh straight season eclipsing 1,000 yards receiving. He also caught a career-best 12 touchdowns last season, giving him 69 in his career.

In Kansas City's march to the Super Bowl, he caught 27 passes for 257 yards with four touchdowns in three playoff games. He had six receptions for 81 yards with a TD in the Super Bowl.

Should he be forced to sit out, that could spell trouble for Kansas City given his familiarity with Mahomes and the fact the Chiefs are introducing several new receivers this year.

Noah Gray, who is listed as Kelce's backup on the depth chart, had 28 catches for 299 yards with a TD for the Chiefs last season.

The Chiefs are hopeful of having Kadarius Toney available for the opener after the wide receiver missed nearly all of training camp with a torn meniscus in his knee.

The Kansas City defense, however, will likely be without Chris Jones as the All-Pro defensive tackle has been holding out while trying to get a long-term contract.