The Cleveland Browns ruled defensive end Myles Garrett out for their Week 4 visit to the Atlanta Falcons after the star pass rusher sustained multiple injuries in a car accident on Monday.

Earlier in the week, the Browns had listed Garrett as questionable, but they announced on Saturday he would sit. 

Garrett suffered a sprained shoulder and strained biceps in the one-vehicle crash and was hospitalised for several hours after his car went off the road and flipped over.

Speaking to reporters for the first time since the crash, Garrett called it "a hell of an event" on Saturday. 

"I feel grateful to be here with what I saw right after and [in] the pictures," Garrett said.

"I'm just grateful not only that I'm alive but that I was able to have so much of my family and the support system that was around me to keep me locked in and keep me focused on taking things day by day."

Police issued Garrett a citation for driving 65 miles per hour in a 45mph zone. 

Garrett said he swerved to avoid hitting an animal and lost control of his Porsche when he "overcorrected" his steering on a wet road. 

All week, Garrett's team-mates have expressed more concern about his wellbeing than his ability to take the field on Sunday. 

"In the grand scheme of life, the best thing is that he's OK," Cleveland quarterback Jacoby Brissett said earlier this week. "When I texted him, I was like, 'man, I'm just glad you're alright'."

Garrett had a career season in 2021 with 16 sacks, 33 quarterback hits and 17 tackles for loss. He has made a solid start this year as he leads the Browns (2-1) with three sacks and five quarterback hits while being tied for the team lead with four tackles for loss and one forced fumble.

"I know he probably wants to [play]," Browns safety John Johnson III said. "But if you asked me, I think he just personally should just sit it out. I think he should just take it easy, man."