The Tampa Bay Buccaneers handed the Green Bay Packers their first loss of the NFL season, while Tua Tagovailoa made his debut as the Miami Dolphins thrashed the New York Jets.
Tom Brady and Aaron Rodgers went head-to-head, and the Buccaneers came out on top at Raymond James Stadium on Sunday.
In Florida, the Dolphins blew out the Jets, leaving New York 0-6 and putting further pressure on under-fire head coach Adam Gase.
In the last game of the day, the San Francisco 49ers bounced back from consecutive losses by beating the Los Angeles Rams.
DEAN SPARKS BUCCANEERS AGAINST PACKERS
With the Buccaneers trailing 10-0, Jamel Dean's pick-six of Rodgers sparked Tampa Bay on the way to a 38-10 victory.
The Buccaneers scored 38 consecutive points, with Brady throwing touchdown passes to Tyler Johnson and Rob Gronkowski in the second quarter.
Brady completed 17 of 27 passes for 166 yards and the two TDs.
The quarterback connected with former New England Patriots team-mate Gronkowski for their 79th TD. They are tied for the fourth most by a duo in NFL history, alongside Dan Marino and Mark Clayton, as per NFL Research. Only Peyton Manning-Marvin Harrison, Philip Rivers-Antonio Gates and Steve Young-Jerry Rice are ahead of them.
Packers star Rodgers threw two interceptions and was sacked four times, finishing with just 160 passing yards after completing 16 of 35.
MORE MISERY FOR JETS AS TUA DEBUTS
Tagovailoa, the fifth pick in the 2020 NFL Draft, came on for his debut in the Dolphins' 24-0 win over the struggling Jets.
He replaced Ryan Fitzpatrick, who had completed 18 of 27 passes for 191 yards, three TDs and two interceptions as the Dolphins improved to 3-3. Tagovailoa completed two passes for nine yards.
Under pressure at the helm of the Jets, Gase said his players were hurting.
"In this locker room, these guys are good guys that work extremely hard. It's frustrating when you talk to them on Monday and you can tell they're hurting," he said.
"They come in to work and do a good job and have high energy at practice. I feel the players are the ones who are trying to flip this thing, they're taking the lead on this. We've just got to keep grinding and find a way to fix these early mistakes to try and flip the game."
49ERS BOUNCE BACK
The 49ers improved to 3-3 courtesy of a 24-16 win over the Rams.
Jimmy Garoppolo threw three touchdown passes – to Deebo Samuel, George Kittle and Brandon Aiyuk – and completed 23 of 33 for 268 yards.
Kittle had 109 receiving yards for San Francisco, including a 44-yarder from Garoppolo for a TD in the second quarter.
Rams QB Jared Goff struggled, completing just 19 of 38 passes for 198 yards, to go with two TDs and an interception.
Week 6 scores:
Tennessee Titans 42-36 Houston Texans
Baltimore Ravens 30-28 Philadelphia Eagles
Atlanta Falcons 40-23 Minnesota Vikings
Pittsburgh Steelers 38-7 Cleveland Browns
Indianapolis Colts 31-27 Cincinnati Bengals
Detroit Lions 34-16 Jacksonville Jaguars
Chicago Bears 23-16 Carolina Panthers
New York Giants 20-19 Washington Football Team
Denver Broncos 18-12 New England Patriots
Miami Dolphins 24-0 New York Jets
Tampa Bay Buccaneers 38-10 Green Bay Packers
San Francisco Giants 24-16 Los Angeles Rams