The Kansas City Chiefs continue to struggle on the heels of a Super Bowl season, falling 38-20 to the Buffalo Bills after a series of self-inflicted mistakes on Sunday. 

Though the Chiefs controlled the ball for much of the AFC title game rematch, running 25 more plays than the Bills, their four turnovers were the difference as they dropped to 2-3 this season. 

Buffalo (4-1) intercepted Patrick Mahomes passes on back-to-back possessions in the third quarter, with Micah Hyde taking the first of those 26 yards for a touchdown after plucking a tipped ball out of the air. 

It was just the second pick-six of Mahomes' career after Week 11 of the 2018 season.

That score consolidated the Bills' advantage after the visitors had reeled off 17 unanswered points in the second quarter to take the lead for good. 

Both touchdowns in that sequence came from the arm of Josh Allen, who hit Emmanuel Sanders for a 35-yard score and Dawson Knox for a 53-yard TD. 

For a few moments early in the fourth quarter, it appeared the Chiefs had forced a key turnover of their own, as Rashad Fenton intercepted Allen inside Bills territory.

But Buffalo retained the ball thanks to a controversial roughing the passer penalty on Frank Clark and made it count, marching downfield before another Allen-to-Saunders touchdown pass with 5:51 to play that effectively sealed the win. 

Allen was 15 of 26 passing for 315 yards (12.1 per attempt) and ran for 59 more, including a touchdown. Mahomes completed just 33 of 43 passes for 272 yards (5.0 per attempt) while running for 61.