Borussia Dortmund will likely be without full-back Julian Ryerson for their DFB-Pokal trip to Wolfsburg, but Nuri Sahin could welcome back Marcel Sabitzer and Waldemar Anton.
All three players were injured during Saturday's 2-1 loss at Augsburg in the Bundesliga, as Dortmund succumbed to a second defeat in four days after squandering a 2-0 lead to lose 5-2 at Real Madrid in the Champions League.
Speaking at Monday's pre-match press conference, coach Sahin told reporters: "I don't have high hopes for Julian Ryerson.
"With Sabi and Waldi, every hour counts. It will only become clear towards kick-off whether they can play."
Sahin is keen to see Dortmund tighten up at the back after losing three of their last five league matches, slipping seven points behind leaders Bayern Munich.
"The goals we're conceding for the effort we're putting in are extreme. That can't happen to us. We're conceding goals too easily by making mistakes," said the former midfielder.
"At the moment, we have so many issues of our own that it doesn't feel so easy."
Dortmund have lost four consecutive matches on their travels in all competitions since their last DFB-Pokal outing, a 4-1 victory at Phonix Lubeck.
They have gone unbeaten through their last three games against Wolfsburg, however, outscoring them 8-1 since suffering a 2-0 defeat at Volkswagen Arena in November 2022.
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