The West Indies now find themselves facing an unassailable 0-2 deficit after suffering a crushing 120-run defeat to Pakistan in their second of three One-Day Internationals in Multan on Friday.
The hosts set the Windies a target of 276 after winning the toss and batting first.
Captain Babar Azam was the catalyst as he got his sixth consecutive score of 50 or more in ODIs with a 93-ball 77, including five fours and one six.
Imam-ul-Haq provided good support with a run-a-ball 72, including six fours.
Alzarri Joseph produced an excellent spell going for just 33 in his 10 overs while picking up two wickets. Akeal Hosein was also brilliant with 3-52 off his 10 overs.
The Windies reply got off to a bad start with Shai Hope, who got 127 not out in the previous game, being dismissed in the first over for just four.
Kyle Mayers and Shamarh Brooks then provided the innings with some stability reaching 71-1 before Mayers was dismissed for 33 at the end of the 10th over.
Brandon King fell shortly after for a duck to leave the Windies 72-3 after 10.4 overs.
After Brooks fell for 42, in the 19th over, with the score on 102, the West Indies lost their final six wickets for just 52 runs to be bundled out for 155.
Mohammad Nawaz produced a game-changing spell for the hosts with 4-19 from his 10 overs while Mohammad Wasim Jr supported well with 3-34 from 4.2 overs.
The third and final ODI will take place on Sunday.