Naseem Shah has been ruled out of Pakistan's third Test against England in Karachi as he continues to struggle with a shoulder injury.

Shah was in clear discomfort with his right shoulder during the opening Test loss in Rawalpindi, though he still managed to pick up five wickets on a flat pitch.

The 19-year-old paceman missed the second Test in Multan, where England secured their first Test series win in Pakistan for 22 years with a thrilling 26-run victory.

The Pakistan Cricket Board (PCB) has confirmed the fast bowler will play no part in the third and final Test, which starts on Saturday.

"A niggle in the bowling shoulder has ruled out Naseem Shah from the third and final Test between Pakistan and England at Karachi," a PCB said in a statement.

"The fast bowler will travel to Lahore where he will undergo further assessment at the National High Performance Centre before beginning rehabilitation.

"The team management has not requested for his replacement at this stage."

Pakistan have also been without fellow quicks Shaheen Shah Afridi and Haris Rauf through injury.