Opening batsman David Warner has been ruled out of the remainder of Australia's four-game Test series against India due to an elbow injury.

Warner was substituted out of the second Test defeat after the first day, having been struck on the grille of his helmet while batting facing Mohammad Siraj during his innings.

The 36-year-old left-hander also copped another delivery to his elbow, with X-rays confirming he had sustained a hairline fracture which will end his Test series at a time when he has been under pressure to hold his spot.

"David Warner has been ruled out of the Qantas test tour of India and will return home," CA said in a statement on Tuesday.

"After further assessment, he will require a period of rehabilitation which will preclude any further involvement in the remainder of the Test series.

"It is currently anticipated that he will return to India for the three One-Day Internationals which follow the Test Series."

Warner's departure follows fast bowler Josh Hazlewood who has been ruled out with Achilles soreness, while captain Pat Cummins has rushed back to Australia for a family health issue.

Australia are 2-0 down in the series, with India having already retained the Border-Gavaskar Trophy following batting collapses by the tourists in both Tests.

Warner had struggled in his three innings with the bat in India, managing only 26 runs, having ended his Test century drought with a double hundred during the Boxing Day Test against South Africa.

Renshaw replaced Warner as a concussion substitute in the second Test, although Travis Head opened the batting in his absence in the second innings.

All-rounder Cameron Green is in line to return for Australia following a finger injury, with the third Test to commence in Indore on Wednesday March 1.