India all-rounder Axar Patel has been ruled out of the opening Test against England, the Board of Control for Cricket in India (BCCI) announced on Friday.
Patel, 27, will sit out the first of four Tests after complaining of pain in his left knee following Thursday's training session.
As a result, spinners Shahbaz Nadeem and Rahul Chahar have been added to the squad, with the opening Test due to get underway in Chennai on Friday.
India are coming off a series victory over Australia, where they were depleted due to injuries in the blockbuster showdown.
Virat Kohli's India have managed to win each of their last 10 multi-game bilateral Test series played on home soil, that run beginning after they suffered a 2-1 series defeat at the hands of England in 2012.
No visiting men's Test side have beaten India at M.A. Chidambaram Stadium during the 21st Century (D3 L5) – Pakistan being the last team to do so in the format (1999).
England have managed to record five overseas Test wins in succession ahead of this match - their longest such run since 1914 (seven in a row between 1911 and 1914).
Joe Root is set to become the 15th man to appear in 100 Test matches for England and has the chance to equal Michael Vaughan's record of 26 Test wins as England skipper (currently 25).