Bowler Mukesh Kumar and batsman Rajat Patidar have earned their first call-ups to India's ODI squad for the three matches against South Africa.
The first match is slated for Thursday in Lucknow, before the second game in Ranchi on October 9. The teams will then face off a final time in Delhi two days later.
Shikhar Dhawan has been named India's captain, while Shreyas Iyer will be vice-captain for the series.
Dhawan is expected to open the batting with Shubman Gill, though Ruturaj Gaikwad is also reportedly in contention for that role.
Patidar will form part of the pace attack, alongside Shardul Thakur, Mohammed Siraj and Avesh Khan.
It is a weaker India squad as none of the members of the T20I set-up have been named in the ODI pool, with those players due to travel to Australia on October 6 ahead of the T20 World Cup.
India squad: Shikhar Dhawan (c), Shreyas Iyer, Ruturaj Gaikwad, Shubhman Gill, Rajat Patidar, Rahul Tripathi, Ishan Kishan, Sanju Samson, Shahbaz Ahmed, Shardul Thakur, Kuldeep Yadav, Ravi Bishnoi, Mukesh Kumar, Avesh Khan, Mohammed Siraj, Deepak Chahar.
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