Steve Smith smashed Australia's third-fastest ODI century and Aaron Finch also made a sublime hundred as India were consigned to a 66-run defeat in the first match of the series.
Smith struck a sensational 105 from just 66 balls and Finch crafted 114 in Australia's massive total of 374-6 - their biggest against India in the 50-over format.
David Warner (69) also made the tourists suffer, while Glenn Maxwell bludgeoned 45 from only 19 balls in Australia's second-highest ODI total at the SCG.
Mohammed Shami (3-59) was comfortably the pick of the India bowlers on a painful Friday afternoon in the field.
Hardik Pandya struck a superb 90 and Shikhar Dhawan made 74, but India, returning to action for the first time since March due to the coronavirus pandemic, fell short on 308-8 in reply.
Josh Hazlewood (3-55) and Adam Zampa (4-54) did the damage with the ball for Australia as they started their summer in style to go 1-0 up in the three-match series.
FINCH AND WARNER MAKE HISTORY
Finch and Warner combined for the highest opening stand for Australia in an ODI at the SCG, their 156 surpassing the record of 152 set by Geoff Marsh and David Boon in 1986.
Shami finally got the breakthrough in the 28th over, snaring Warner caught behind after Virat Kohli reviewed, but Finch and Smith dished out more punishment, putting on 108 in just 12 overs.
The brilliant Finch struck two sixes and another nine fours in his fourth ODI century against India, a tally only Ricky Ponting has bettered with six, before the skipper became Jasprit Bumrah's only victim.
SENSATIONAL SMITH AND MAXWELL GO BESERK
While Finch uncharacteristically scored at less than a run a ball, Smith raced to a magnificent hundred which he reached off 62 balls.
Smith failed to hit the heights during the recent Indian Premier League but produced a disdainful knock as he dispatched the tourists' attack to all parts - Yuzvendra Chahal (1-89) conceding the most runs by an India spinner in an ODI.
The imperious Smith hit four sixes and 11 fours as he put on a show along with Maxwell, who treated the crowd to some astonishing innovative strokes in an explosive innings.
HAZLEWOOD AND ZAMPA DERAIL INDIA CHASE
India's run chase got off to a blistering start, Mitchell Starc conceding 20 off an 11-ball first over, but they were struggling on 101-4 in the 14th over - Kohli making just 21 after he was dropped by Zampa on one.
Hazlewood had Kohli caught by Finch at midwicket and the quick also saw the back of Mayank Agarwal and Shreyas Iyer.
Dhawan - dropped by Maxwell on 41 - and Pandya - playing as a specialist batsman - gave India hope with a fifth-wicket stand of 128, but spinner Zampa removed both in quick succession and got rid of Ravindra Jadeja in an ultimately comfortable win for Australia.