Five touchdowns for Taylor as Colts stun Bills, Heinicke sees off Newton
The star running back became just the 13th player since 1960 to bag five or more scrimmage TDs in a game, and the first from the Colts to achieve the feat.
Taylor came into the game having scored a rushing touchdown in seven straight games, looking to become the first to reach eight since DeAngelo Williams in 2008.
What transpired was a momentous day for the 22-year-old, who was a second-round pick in the 2020 draft, and he pushed the Colts to 6-5 for the season, after their 1-4 start.
He scored from the Colts' opening drive and was unrelenting from that point on.
The Bills, top of the NFL team defense ranking heading into the game and boasting an average winning margin of 26.3 points this year, had little answer to Taylor's breath-taking display and slipped to 6-4.
This was a rematch of a wildcard round in last year's playoffs, when the Colts were edged out, and Taylor ensured the outcome was markedly different.
He told CBS: "The offensive line and I, we prepared tremendously throughout this week. We knew it was going to be a tough challenge.
"We had to accept that challenge, that's what we had to do coming into this game and that was half of the battle."
Asked what the secret had been to his recent success, Taylor said: "I think it's been the communication between the offensive line and myself.
"It doesn't matter what defensive front they bring, what pressure, as long as we're all in communication and on the same page we can accomplish anything."
He saluted the Colts' defense, who snagged three interceptions, saying: "A lot of those guys were coming up to me, talking about the game I had today. They create and generate takeovers, and we have to capitalise on them."
The Colts' five previous wins this year had come against teams with a combined 13-34 record, with this victory suggesting they can mix it with higher pedigree sides.
Newton loses out to Heinicke
Cam Newton's first start of his second stint with the Carolina Panthers ended in defeat at home, a 27-21 loss to Taylor Heinicke and Ron Rivera's Washington Football Team.
He finished 21-of-27 for 189 yards, with touchdown passes for DJ Moore and Christian McCaffrey. Newton also rushed for a touchdown, but against his old Panthers coach Rivera it was not Newton's night, and his contribution waned late on.
Heinicke finished 16-of-22 for 206 yds with three touchdown passes to help Washington improve to 4-6, earning another prized scalp after topping Tom Brady's Tampa Bay Buccaneers in Week 10.
Vikings pick off Packers as Joseph wins it
Greg Joseph's last-gasp field goal gave the Minnesota Vikings a stunning 34-31 win over the Green Bay Packers at U.S. Bank Stadium.
His walk-off 29-yard glory kick settled a tumultuous game that had seen the Vikings lead 23-10, only to be overhauled and trail at one point in the fourth quarter.
It became a ding-dong battle from there and overtime looked to be on the cards after Aaron Rodgers sent a 75-yard touchdown pass to Marquez Valdes-Scantling to tie it at 31-31 in the fading moments.
Yet Minnesota made ground and gave Joseph the chance to win it, meaning they improved to 5-5 and the NFC North leading Packers slipped slightly to 8-3.
Rodgers went 23-of-33 for 385 yards with four touchdown passes.