The one-time Pro Bowler saw his game curtailed during Sunday's loss to the Los Angeles Chargers, after outside linebacker Khalil Mack landed on his foot.
Tannehill was carted from the field before returning with his ankle heavily strapped, though he was unable to prevent the Titans slipping to a 17-14 defeat.
Reports from ESPN now indicate the 34-year-old's campaign looks to be over, with the former Miami Dolphins man set to undergo an operation for the problem.
It was a right ankle injury that ruled Tannehill out of two games following a week six match with the Indianapolis Colts, bringing Malik Willis into the fold in his place.
The reserve quarterback started in practice on Tuesday and Wednesday, while the Titans have also signed Joshua Dobbs to provide additional backup.
The latter was with the Detroit Lions briefly as part of their practice squad earlier this month, after he was waived following Deshaun Watson's return to the fold at the Cleveland Browns.
Tennessee are 7-7 for the year, and sit atop the AFC South, but have not won in their last four outings to leave their postseason hopes precariously balanced heading into the final few weeks.
They play the Houston Texans on Saturday, before closing games against the Dallas Cowboys and the Jacksonville Jaguars, with the latter their main rival to top the division.
The Titans confirmed the roster moves on Friday, a day after pass rusher Cameron Wake and running back Dion Lewis were also cut ahead of a key offseason for the team.
After reaching the AFC Championship game, big decisions need to be made on free agent quarterback Ryan Tannehill and running back Derrick Henry, with the franchise and transition tags at their disposal.
The Titans have also been linked with a pursuit of New England Patriots QB Tom Brady when free agency begins on March 18.
Tight end Walker spent seven years with the Titans, racking up 5,888 yards and 36 touchdowns in making three Pro Bowls, but an ankle injury restricted him to just eight games over the past two seasons and he was released with a failed physical designation.
"In my time here with Delanie, he has been an absolute pro on the field, in the locker room, and his production speaks for itself," Titans general manager Jon Robinson said.
"He was a leader, a captain, and a highly respected member of this team. His toughness, competitiveness, attitude and professionalism are what we expect from our players. I want to wish him all of the best moving forward and he will forever be a Titan great.
"Over the last two days I have had the difficult task of informing a number of our players they are being released.
"These aren't easy conversations, but I want to thank each of them for the significant contributions they have made to our organisation."
The Minnesota Vikings made moves as they released cornerback Xavier Rhodes and defensive tackle Linval Joseph, while vowing to "remain in communication" with both players during free agency with a view to re-signing them.
"Both Linval and Xavier have personified what it means to be a Minnesota Viking since joining our organisation, providing incredible leadership on the field, in the locker room and within the community," said GM Rick Spielman.
Tackle Cordy Glenn was released by the Cincinnati Bengals, saving the team $9.5million in cap space.
Titans controlling owner Amy Adams Strunk informed Robinson he was relieved of his duties following a 35-10 defeat to the Philadelphia Eagles on Sunday.
Although 7-5 Tennessee are top of the AFC South, they have suffered back-to-back defeats and the division stands as the weakest in the NFL – with none of the four sides currently on a winning streak.
Vice president of player personnel Ryan Cowden will take the reigns for the remainder of the season, with a "comprehensive search" beginning once the campaign is complete.
Adams Strunk said in a statement: "Since becoming controlling owner in 2015, my goal has been to raise the standard for what is expected in all facets of our organisation.
"I believe we have made significant progress both on and off the field through investments in leadership, personnel and new ideas.
"This progress includes the core of our business, the football team itself, which is regularly evaluated both by results (wins and losses) and team construction/roster building.
"I am proud of what we have accomplished in my eight seasons of ownership, but I believe there is more to be done and higher aspirations to be met."
The Titans host the Jacksonville Jaguars in Week 14, with three of their remaining five games taking place in Tennessee.
The running back has not played since injuring in his foot in a win over the Indianapolis Colts back in Week 8.
Henry endured a frustrating spell on the sidelines following surgery, but is back for the Divisional Round showdown with the fourth-seeded Bengals at Nissan Stadium.
The 2020 NFL Offensive Player of the Year came through contact training this week and is ready to make a timely comeback.
Henry said: "I felt great. I just wanted to get some pads on. Haven't had them on in a while and got some contact going."
The two-time Pro-Bowler rushed for 937 yards and 10 touchdowns in 219 carries in his eight regular-season games for the top-seeded Titans this season.
Henry was leading the league in rushing when he sustained the injury.
He made 112 yards from 18 carries, scoring one touchdown when the Titans last faced the Bengals in November 2020, a game that was won 31-20 by Cincinnati.
The Titans improved to 6-2 with their 34-31 overtime victory in Indianapolis on Sunday.
However, it may have come at a massive cost, with ESPN's Adam Schefter reporting Henry could now miss the remainder of the campaign.
Subsequent reports have revealed Henry is believed to have broken a bone in his foot and is set to undergo an MRI scan.
It is tough to oversell Henry's importance to the Titans, who have leaned on the running back as the undisputed focal point of their offense for the last three seasons.
This season, Henry has produced consistency to put him in position to threaten Eric Dickerson's record for rushing yards in a single season.
He leads the NFL with 947 yards, 288 more than his nearest challenger, the Colts' Jonathan Taylor.
Averaging 117.1 yards per game, he is on pace for 1,990, though several more performances of 100 yards or more could put him within striking distance of the 2,105 Dickerson racked up in 1984.
Now that record seems set to stand, with the AFC South-leading Titans likely to put more of the burden on quarterback Ryan Tannehill in Henry's absence.
Henry had continued to deliver despite a workload that would see lesser running backs break down under the strain.
He carried the ball a league-leading 303 times in 2019 and increased that number to 379 last season, winning the rushing title in back-to-back years.
The former Alabama star had already tallied 219 rush attempts this season, with backup Jeremy McNichols used predominantly as a pass-catcher.
Tennessee will not lean on McNichols or Darrynton Evans in the same way, meaning the onus will be on Tannehill to lead the Titans on what they hope will be a deep playoff run.
The star running back is reported to have suffered a broken bone, with Titans coach Mike Vrabel saying Henry will "work extremely hard to get back".
The Titans have leaned on Henry as the focal point of their offense for the last three seasons and his absence will come as a major setback.
Tennessee improved to 6-2 with their 34-31 overtime victory in Indianapolis on Sunday, but Henry was placed on injured reserve a day later.
"Derrick is going to have surgery in the morning [on Tuesday]," Vrabel said, quoted on the Titans' official website. "We are not going to put a timeline on when he may return.
"I know that he'll do everything that he can to work himself back, to be able to help this football team. And whenever that is, that's when it will be."
This year, Henry has produced consistency that was putting put him in position to threaten Eric Dickerson's 1984 record of 2,105 rushing yards in a single season.
He leads the NFL with 937 yards, 288 more than his nearest challenger, the Colts' Jonathan Taylor.
Henry carried the ball a league-leading 303 times in 2019 and increased that number to 379 last season, winning the rushing title in back-to-back years.
The former Alabama star had already tallied 219 rush attempts this season, putting him way out ahead in the NFL, with backup Jeremy McNichols used predominantly as a pass-catcher.
Vrabel said: "We'll have to move on unfortunately without him in the short term, and not look back. I hate to speak for our players, but Derrick is disappointed, everybody is.
"We spent a lot of time together with the coaching staff and with the players, so you never want to see any of them injured in any capacity. So I know that Derrick is going to work extremely hard to get back to do everything he can to help this football team."
Dickerson's record no longer appears to be in any danger, and the AFC South-leading Titans are likely to put an increased burden on quarterback Ryan Tannehill in Henry's absence.
Henry was earlier designated to return from injured reserve, opening his 21-day window to be placed back on the active roster.
The star running back suffered a fractured foot in the Titans' overtime win against the Indianapolis Colts back on October 31.
Henry, who won the rushing title in 2019 and 2020, has 937 yards on 219 attempts with 10 touchdowns in the 2021 season.
Despite his return to practice, it appears unlikely he will be ready to feature in the Titans' regular-season finale against the Houston Texans, in which they could clinch the number one seed in the AFC.
However, should Tennessee indeed secure top spot in the conference, it will give the Titans a first-round bye and Henry extra time to recover for a home game in the Divisional Round.
Even with Henry missing half the season, the Titans still rank third in rush yards per game with 142.5 and will hope his return to their ground attack can help propel them to a second Super Bowl appearance in franchise history.
The move ensures 2019 Pro Bowler and Titans star Henry is officially under contract for the 2020 season.
Tennessee have until July 15 to negotiate a long-term deal to replace the franchise tag.
On Wednesday, Titans general manager Jon Robinson said: "I think any time a player, when you have to use the tag on them, that's something that ideally they probably don't want.
"But still, at the same time, I know that he wants to be a part of this football team and I thought it was good that they communicated back he does want to be here, and he does want to keep working on this thing.
"It wasn't something like, 'OK, well, I'll take the [tag] and I'm done, or I am just going to do whatever.' He wants to be here, and he conveyed the message to me, through his agent, that he wants to keep working on this thing and we do, too."
Henry led the NFL in rushing in 2019, finishing the regular season with 1,540 yards and 16 touchdowns as Tennessee made the playoffs.
The 26-year-old also played a pivotal role in their run to the AFC Championship Game, going for 182 and 195 yards respectively in upset road wins over the New England Patriots and the Baltimore Ravens.
Rams quarterback Matthew Stafford threw two interceptions in a 26-second span early in the second quarter, leading to a pair of rapid-fire Titans touchdowns.
The first was an ill-advised attempt to throw the ball away while being dragged down in the end zone that David Long intercepted at the Rams' eight-yard line.
After Geoff Swaim scored on a two-yard TD pass from Titans QB Ryan Tannehill on the ensuing play, Stafford's next pass was picked off and returned 24 yards for a TD by Kevin Byard.
Tannehill would run the ball in for another score prior to half-time as the Titans built a 21-3 lead before handing the game over to their ferocious defence, which sacked Stafford five times after LA entered the game with only eight sacks allowed all season.
Titans recruit Adrian Peterson scored his 125th career TD, joining 11 other players to score 125-plus career touchdowns.
The Rams (7-2) would not find the end zone until Stafford hit Sony Michel for a short TD with 24 seconds remaining in the game as they fell behind the victorious Arizona Cardinals (8-1) in the division race.
Tennessee (7-2) now hold the best record in the AFC despite being out-gained 347-194 as star running back Derrick Henry remains sidelined with a foot injury.
Tannehill completed 19 of 27 passes for just 143 yards with a TD and an interception but his 79.7 passer rating was still better than Stafford's 71.0 after the Rams QB finished 31-of-48 passing for 294 yards.
Tennessee caused an upset when they shocked reigning champions the New England Patriots in the wild-card clash last week to earn a trip to the divisional round.
And the Titans – 9-7 in the regular season – defied the odds again with a sensational 28-12 victory away to Lamar Jackson's Ravens in Baltimore, where Derrick Henry starred on Saturday.
Through to their first AFC championship game since 2002, the Titans will next face either the Kansas City Chiefs or Houston Texans.
Coming off the bye week and a franchise-record 14-2 season, confidence was high within the Ravens camp, but the top seeds found themselves trailing from the outset.
Titans quarterback Ryan Tannehill, who finished seven of 14 for 88 yards and a pair of touchdowns to go with a rushing TD, and his 12-yard throw to Jonnu Smith with less than four minutes remaining in the opening quarter gave Tennessee a 7-0 lead.
Another Tannehill pass, this time a 45-yard throw to Kalif Raymond early in the second quarter, extended the Titans' lead amid silence in front of Ravens fans in Baltimore.
A pair of Justin Tucker field goals gave the Ravens their first points as they went into the half-time break trailing 14-6.
The Titans oozed confidence in the second half and a sequence of brilliance from running back Henry stretched Tennessee's advantage against Baltimore.
After his breathtaking 66-yard run, Henry put the Titans in the red zone and he capped the drive with a jump-pass touchdown throw to Corey Davis as back-up quarterback Marcus Mariota motioned out of the backfield.
Tannehill returned to the field moments later and rushed for a one-yard touchdown – the Titans ending the third period with a commanding 28-6 lead.
Frustrated, Ravens star Jackson – 31 of 59 for 365 yards, a touchdown, two interceptions and four sacks – gave Baltimore some hope with a TD pass to Hayden Hurst with just over 11 minutes remaining in the contest but the Titans were too good.
The Titans went into Sunday's encounter on a six-game winning streak, including victories over the Buffalo Bills, Kansas City Chiefs and Los Angeles Rams.
But that was remarkably ended by the Texans, who claimed only their second win of the season with a 22-13 triumph in sodden conditions.
Ryan Tannehill was intercepted four times, with a Titans attack missing Derrick Henry and Julio Jones scoring just 13 points against a Texans team that has given up the fourth-most (264) in the NFL.
The Titans also lost top receiver A.J. Brown to a chest injury, but neither Vrabel nor Tannehill made any excuses for a dismal offensive showing.
"I think we've seen Ryan perform at a high level," Vrabel said. "Offensive football at any level takes 11 guys.
"There was a lot of good football out there, unfortunately we turned the football over too many times. Our defense battled. Our offense was its own worst enemy."
Tannehill added: "We just kept shooting ourselves in the foot you know?
"Turnovers, turnover on downs, penalties. We shot ourselves in the foot all day. And we got to get better and it starts with me."
The Titans remain in top spot in the AFC with an 8-3 record, but could be unseated by the New England Patriots (7-4) should they lose in Foxborough in Week 12.
Peterson was signed to the Titans' 53-man roster earlier this month after star running back Derrick Henry's season-ending foot injury.
However, the Titans waived the 36-year-old and 2012 NFL MVP after only three games.
Peterson debuted for the Titans in the 28-16 win over the Los Angeles Rams in Week 9 – he scored with a one-yard touchdown.
The veteran rushed for 82 yards across 27 carries as well as four receptions for eight yards in his three games for the Titans, who are 8-3 for the season and top of the AFC South.
The decision on Peterson was one of 13 roster moves made by the Titans on Tuesday, including adding defensive back Buster Skrine, running back Dontrell Hilliard and outside linebacker John Simo to their active roster.
A COVID-19 outbreak within the Titans' organisation forced the NFL to postponed Sunday's clash in Tennessee, where last week's Week 4 showdown against the Pittsburgh Steelers had to be postponed until later this month.
The Titans' (3-0) meeting with the Bills (4-0) is now set to be played at Nissan Stadium on Tuesday, with the Denver Broncos-New England Patriots showdown moved to Monday.
"These scheduling decisions were made to ensure the health and safety of players, coaches and game day personnel and in consultation with medical experts," the league stated in the announcement.
Should the matchup between the Titans and Bills be played on Tuesday, the Week 6 fixture involving the Kansas City Chiefs and Buffalo will be moved from October 15 to later in the weekend.
The Titans are yet to return to their facility following the spate of positive tests and, on Thursday, NFL Network and ESPN both reported a fresh instance of a player contracting COVID-19.
In addition, an inconclusive positive test from Wednesday has now been confirmed as a definite positive, meaning that, since September 24, Tennessee have had 12 players and nine personnel staff contract the virus.
Whereas other teams have reported isolated or just a few cases, the Titans' large number has led to an NFL investigation into the possible cause of the outbreak.
The Patriots played Super Bowl champions the Chiefs on Monday – a day later than planned because of positive COVID-19 tests for both teams.
Stephon Gilmore became the second high-profile Pats player to return a positive test on Wednesday after quarterback Cam Newton did so last week, but there were reports every Patriots player tested negative when the latest results were returned on Thursday.
On Tuesday, the Titans confirmed three players and five personnel staff had contracted COVID-19, while NFL Network reported another player had tested positive on Wednesday.
An NFL statement read: "The Steelers-Titans game, originally scheduled for Sunday at 1pm ET, will be rescheduled to allow additional time for further daily COVID-19 testing and to ensure the health and safety of players, coaches and game-day personnel.
"Details on the new game date and time on either Monday or Tuesday will be announced as soon as possible".
Though the entire NFL preseason slate was scrapped this year, this is the first instance of a regular season game being postponed because of the COVID crisis.
So while the soap opera between Dak Prescott and the Dallas Cowboys gets to air another year after the two sides failed to work out a contract that would have put the talented quarterback among the NFL's highest-paid players, a few other teams were busy locking up vital players amid less fanfare.
Derrick Henry will still be pounding the rock for the Tennessee Titans for the foreseeable future, the Cleveland Browns made Myles Garrett the league's highest-paid defensive player and the Kansas City Chiefs will have defensive lineman Chris Jones on board for what should be an extended window for another Super Bowl run.
When breaking down those aforementioned agreements, it appears all three teams were able to get good value even in what's arguably been the most volatile offseason in league history.
Let's start with Henry. On the surface, the four-year, $50 million contract the Titans gave the 2019 NFL rushing champion looks rather risky considering the often short shelf life of running backs and how a similar pact the Los Angeles Rams constructed with Todd Gurley two summers ago spectacularly backfired.
But Tennessee wisely front-loaded the deal, with most of the $25.5 million in guarantees on the books for the first two seasons, and can cut bait without much penalty after 2021 in the event Henry begins to show a steep decline.
It's not hyperbole to suggest that Ryan Tannehill's breakthrough 2019 season was a direct result of the threat Henry presented to opposing defenses as a runner. By extending their most important player, the Titans have not only given their quarterback his best chance to succeed, they've increased their chances of again contending for an AFC title for at least the next two years.
Of course, the road to an AFC championship still figures to go through Kansas City following the reigning Super Bowl champions' massive recent spending spree that resulted in 2018 NFL MVP Patrick Mahomes landing a record 10-year extension worth up to $503 million and Jones agreeing to a four-year, $80 million deal.
The Chiefs will have some tough decisions to make to get under the salary cap once the big money in Mahomes' contract kicks in after this season, but they've rightfully identified Jones, whose 24.5 sacks over the last two seasons trails only Aaron Donald for the most among interior defensive linemen, as a player to keep.
And the 2019 Pro Bowler gets the benefits of some long-term security and the chance to reach free agency at the relatively young age of 30 - not to mention the opportunity to realistically add a few more rings to his collection.
Extending Garrett may not have been an urgent matter for the Browns, as the 2017 number one overall pick still had two seasons remaining on his rookie contract, but the five-year, $125 million extension was a shrewd, forward-thinking move by new general manager Andrew Berry.
Sure, $25 million a year for a non-quarterback is a lot of coin, but Cleveland has the most cap space in the league right now and with the way the pass-rusher market has been trending, that annual salary could be a relative bargain down the road if Garrett continues to produce double-digit sacks towards the latter end of the deal.
After years and years of bumbling leadership hires, the Browns just maybe have finally gotten it right this winter with the additions of two impressive young minds in Berry and new coach Kevin Stefanski.
It's still way too early to gauge the impact the coronavirus will ultimately have on the NFL's economic landscape in the coming years, but the Titans, Chiefs and Browns at least appear to have positioned themselves well for the potential pitfalls that may lie ahead.
The Titans had until 16:00 ET to reach an agreement with the 2019 NFL rushing leader, who previously accepted his franchise tender and would have earned $10.3m this season without a new contract.
Henry's new deal is the fourth-largest active contract for a running back, behind only Dallas' Ezekiel Elliott (six years, $90m), Carolina's Christian McCaffrey (four years, $64m) and the New York Jets' Le'Veon Bell (four years, $52.5m).
The 2015 Heisman Trophy winner earned his big payday by leading the NFL with 1,540 rushing yards and tying for the league lead with 16 rushing touchdowns during a breakout 2019 regular season. Henry then helped Tennessee advance to the AFC Championship game by rushing for a combined 377 yards in the Titans' upset playoff wins at the New England Patriots and Baltimore Ravens.
Henry's rushing yardage total was the fourth-highest in a season in franchise history, and the most since Chris Johnson led the NFL with 2,006 in 2009.
A second-round pick by Tennessee in the 2016 draft, Henry is the second significant offensive player the team has locked up with a long-term deal this offseason. The Titans were able to re-sign starting quarterback Ryan Tannehill to a four-year, $118m contract in March.
The Titans' clash with the Buffalo Bills was put back two days to Tuesday by the NFL as a result of COVID-19 cases.
Tennessee were able to return to their training facility on Saturday after no positive tests were found for two days in a row.
However, they have now been forced to close it down just a couple of days before they are due to face the Bills at Nissan Stadium.
A Titans statement said: "This morning we learned that a staff member tested positive. We have temporarily closed our facility and are in communication with the league on the next steps."
The Titans' Week 4 showdown against the Pittsburgh Steelers had to be postponed until later this month.
The New England Patriots' training facility was also shut down again on Sunday amid reports of a new coronavirus case, putting their Week 5 game against the Denver Broncos in doubt.
Patriots cornerback Stephon Gilmore had reportedly tested positive for COVID-19 on Wednesday, becoming the team's second high-profile case after Cam Newton.
Quarterback Newton had missed the Week 4 encounter with the Kansas City Chiefs, with that game pushed back a day as a result of isolated cases for both teams.
New England, beaten 26-10 by reigning champions the Chiefs, had been able to return to the practice field on Saturday, having received no further positive results up to that point.
Brady and defending champions the Patriots were upstaged 20-13 by the Tennessee Titans in Saturday's AFC wild-card clash.
It was New England's first wild-card appearance in a decade as their hopes of back-to-back Super Bowl championships were dashed in Foxborough.
Attention quickly turned to Brady and his future post-game, with the 42-year-old quarterback set to become a free agent.
Asked about potential retirement, six-time Super Bowl champion Brady told reporters: "I would say it's pretty unlikely... Hopefully unlikely."
Brady's contract does not allow the Patriots to use the franchise tag on the three-time MVP, who was 20 of 37 for 209 yards and an interception against the Titans.
"I love the Patriots. They have the greatest organisation," Brady said in a news conference. "Playing for [owner] Mr. [Robert] Kraft all these years and head coach [Bill] Belichick, there's nobody who has had a better career than me, just being with them. I'm very blessed. I don't know what the future looks like, so I'm not going to predict it."
"I don't want to get too much into the future. This team has fought hard. We work hard to improve. It's proud to be part of this team every year," Brady continued."
"I don't know what's going to happen. No one needs to make choices at this point. I love playing football. I love playing for this team, I love playing for this team for two decades and winning a lot of games."
On Patriots fans, Brady – who was drafted by New England in 2000 – added: "I personally appreciate everything they've contributed over the course of not just this year but a lot of years. Grateful for the experience of playing for this organisation this year and over the course of my career too.
"I hope I've always tried to do the right thing out there. Who knows what the future holds, so we'll leave it at that."
The game was postponed to Tuesday following a spate of positive coronavirus tests for the Titans, which led to their training facility being closed.
It meant Vrabel's team had just three practices in 16 days, but that did not stop them dominating at LP Field, where Derrick Henry rushed for two touchdowns and Ryan Tannehill completed 21 of 28 passes for 195 yards and three TDs.
The display filled Vrabel with pride and confidence that his men can overcome any difficulties to prevail.
"I'm never going to question this football team. I'm never going to question the effort," Vrabel said, per ESPN.
"I'm never going to go into a game questioning how we're going to do. I expect us to win and play with great effort.
"You don't all of a sudden galvanise when things are bad. I think that's a testament to the players and what we've tried to build here.
"You don't always say, 'Oh, there's a s***-storm. We better galvanise.' You stay tight throughout, and you hope that the fundamentals and your core beliefs and core values take over when things get difficult."
The clash was tied after the opening quarter, in which Isaiah McKenzie scored after Tannehill and A.J. Brown connected on a 16-yard pass.
Henry surged over to reclaim the lead for the Titans in the second quarter and Tannehill's 10-yard run saw them into a 21-10 half-time advantage.
Quarterback Josh Allen, who went 26 of 41 for 263 yards with two TDs for the Bills, threw one of his two interceptions to Malcolm Butler in the third quarter and the Titans capitalised through a Jonnu Smith TD.
Given plenty of time, Allen found T.J. Yeldon with a 22-yard pass into the end zone in the fourth quarter, but Henry and Smith ensured the Titans pulled away for a comprehensive victory.
The Titans are top of the AFC South, while the Bills (4-1) remain in first place in the AFC East.
The Titans were 10-0 down at half-time, but touchdowns from D'Onta Freeman and the returning A.J. Brown put them in front.
Niners quarterback Jimmy Garoppolo, who completed 26 of 35 passes for 322 yards, threw his only TD pass for Brandon Aiyuk to level the game in the fourth quarter.
Randy Bullock had the final say, though, making no mistake with a field goal with four seconds left, ensuring Tennessee (10-5) can win the AFC South if the Arizona Cardinals beat the Indianapolis Colts on Sunday.
Titans head coach Vrabel said: "The funeral for the Titans was supposed to be yesterday or today. We're not dead yet."
Brown was making his first appearance since Week 11 after recovering from a chest injury and certainly made his presence felt.
The wide receiver took a career-high 11 catches for 145 yards and was able to celebrate a long-awaited touchdown.
Vrabel said of Brown: "We understand how important he is to our football team. Love him as a person. Glad to have him back."
He added: "A.J''s fantastic. We expect those things from A.J."
Ryan Tannehill threw 22 of 29 passes for 209 yards while Brown finished with 11 receptions for 145 yards.
Defeat for the 49ers (8-7) ensured the Dallas Cowboys (10-4) will feature in the playoffs for the first time in three years.
Dallas (10-4) clinched its first playoff berth in three years Thursday, thanks to the Tennessee Titans' 20-17 victory over the San Francisco 49ers.
